Description
Ceftazidime & Sulbactam Injection
Healthy Inc is a specialized global supplier and exporter of synergistic antibiotic combinations. We provide high-purity Ceftazidime & Sulbactam Injection (1.5g / 2.25g), sourced from WHO–GMP certified sterile injectable facilities. This “Broad-Spectrum Shield” is a top export to general surgery wards, renal units, and government health ministries in Africa, LATAM, and Southeast Asia, serving as a cost-effective solution for mixed aerobic-anaerobic infections where Ceftazidime alone may fail.
Product Overview
This formulation combines Ceftazidime, a third-generation antipseudomonal cephalosporin, with Sulbactam, a beta-lactamase inhibitor.
The “Enhanced Stability” Specialist:
- Synergy (The “One-Two Punch”): Sulbactam protects Ceftazidime from hydrolysis by common beta-lactamases produced by bacteria like Staphylococcus aureus and Bacteroides fragilis. This extends the spectrum of Ceftazidime beyond just Gram-negatives to include many anaerobes and Gram-positives.
- Acinetobacter Activity: Unlike Tazobactam, Sulbactam itself has intrinsic antibacterial activity against Acinetobacter baumannii, a notorious hospital superbug. This makes the Ceftazidime-Sulbactam combo particularly useful in ICUs battling Acinetobacter outbreaks.
- Cost-Effective: It offers a broader spectrum than Ceftazidime alone at a lower cost point than Carbapenems, making it an ideal “workhorse” antibiotic for developing markets.
Product Composition & Strength
We supply this product as a Sterile Dry Powder for Injection in glass vials. The standard ratio is either 2:1 or 1:1 depending on the market requirement.
| Strength Variant | Ceftazidime Content | Sulbactam Content | Ratio |
|---|---|---|---|
| 1.5 g Vial | 1000 mg (1 g) | 500 mg (Sodium) | 2:1 (Standard) |
| 2.25 g Vial | 1125 mg | 1125 mg | 1:1 (High Potency) |
| Excipients | Sodium Carbonate | Buffer | – |
*Pack Sizes: Tray of 1 Vial or Box of 1/10 Vials with Water for Injection (WFI).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.20.19 (Medicaments containing other antibiotics) |
| Dosage Form | Powder for Injection (Dry Blend) |
| Packaging | Type I Glass Vial (Sterile) with Flip-off Seal |
| Storage | Store below 25°C. Protect from Light. Reconstituted solution stable for 6 hours at room temp. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Hygroscopicity Control: Sulbactam Sodium is highly hygroscopic (absorbs moisture). We process this combination in ultra-low humidity zones (< 20% RH) to prevent the powder from clumping or turning yellow inside the vial.
- Compatibility Testing: Ceftazidime is acidic while Sulbactam is slightly basic. Our formulation uses precise buffering to ensure that when water is added, the solution reaches a neutral pH (6.0-7.5) instantly, preventing pain upon injection and chemical degradation.
Therapeutic Indications (Human Use)
Indicated for the treatment of moderate to severe infections:
- Lower Respiratory Tract: Pneumonia and Lung Abscess (mixed flora).
- Skin & Soft Tissue: Diabetic foot infections, burns, and surgical wound infections.
- Urinary Tract: Complicated UTIs caused by resistant E. coli or Pseudomonas.
- Intra-abdominal: Peritonitis (coverage against Bacteroides).
- Bone & Joint: Osteomyelitis.
Dosage & Administration
Recommended Dosage (Strictly as per Physician):
- Route: Intravenous (IV) or Intramuscular (IM) Injection.
- Adults: 1.5 g to 3 g every 8 hours. Maximum 9 g/day.
- Children: 30-50 mg/kg/day divided into 2-3 doses.
- Administration:
- IV: Dissolve in 10ml WFI and inject slowly over 3-5 minutes or infuse over 30 mins.
- IM: Dissolve in 3ml WFI (or 1% Lidocaine) and inject deep into the gluteal muscle.
- Warning: Releases gas (CO2) upon reconstitution. Vent the vial.
Safety Warnings (CRITICAL):
- Penicillin Allergy: CONTRAINDICATED in patients with a history of anaphylaxis to penicillins or cephalosporins.
- Bleeding Risk: High doses of Ceftazidime can prolong Prothrombin Time (PT). Monitor clotting in patients on blood thinners.
- Renal Function: Both drugs are eliminated by the kidneys. Dose reduction is required in renal failure.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
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