Description

Adefovir Dipivoxil Tablets (10 mg)

Healthy Inc is a premier global supplier of high-precision antiviral therapies. We provide premium Adefovir Dipivoxil Tablets, manufactured in WHO–GMP certified specialized anti-infective units. As a frontline treatment for chronic Hepatitis B, this product is a vital export for liver specialty clinics, infectious disease centers, and Ministry of Health (MOH) tenders in Southeast Asia, Africa, and the CIS region.

Product Overview

Adefovir Dipivoxil is an orally administered nucleotide analog of adenosine monophosphate. It is a prodrug specifically engineered to inhibit the Hepatitis B Virus (HBV) reverse transcriptase, effectively suppressing viral replication in patients with chronic HBV infection.

The “Hepatitis B Suppression” Specialist:

• Mechanism of Action: Adefovir Dipivoxil is phosphorylated by cellular kinases to the active metabolite, adefovir diphosphate. This metabolite competes with the natural substrate, deoxyadenosine triphosphate, for viral DNA polymerase, causing DNA chain termination and stopping the synthesis of viral DNA.
• Broad Efficacy: It is effective against both wild-type HBV and strains resistant to Lamivudine (YMDD mutants), making it a critical secondary line of defense in complex chronic cases.
• Renal-Kinetic Precision: Our 10 mg formulation is optimized for a once-daily dosing schedule, providing a balance between effective viral suppression and a manageable safety profile regarding renal function.

Technical & Manufacturing Specifications

Formulated for absolute dosage accuracy and molecular stability against hydrolysis.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.

• Stability Engineering: Adefovir Dipivoxil is sensitive to moisture, which can cause premature cleavage of the dipivoxil moiety. We utilize low-humidity manufacturing suites and high-barrier Alu-Alu packaging to ensure a 24-month shelf life.
• Purity Assurance: Using validated HPLC methodology, we screen every batch for related substances and degradation products, ensuring the highest purity for patients undergoing long-term chronic therapy.
• Consistent Bioavailability: Our formulation ensures rapid disintegration and optimal conversion of the prodrug into systemic Adefovir, providing predictable viral load reduction across patient populations.

Therapeutic Indications & Clinical Symptoms

• Chronic Hepatitis B: Treatment of chronic HBV infection in adults with evidence of active viral replication and either persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
• HBeAg Positive/Negative: Effective in both HBeAg-positive and HBeAg-negative chronic hepatitis B.
• Lamivudine-Resistant HBV: Management of patients who have developed resistance to previous nucleoside therapies.

Dosage & Administration

• Adult Dosage: One 10 mg tablet once daily, taken orally with or without food.
• Renal Monitoring: Baseline and periodic monitoring of serum creatinine and calculated creatinine clearance is mandatory. Dose interval adjustment is required for patients with pre-existing renal impairment.
• Safety Note: Patients should be monitored closely for lactic acidosis and severe hepatomegaly with steatosis. Discontinuation of therapy may lead to severe acute exacerbations of hepatitis.

Global Export & Contract Manufacturing Services

Healthy Inc is a verified Antiviral Exporter in Mumbai, catering to Hepatology Centers and Ministry of Health Tenders. We offer Third Party Manufacturing for Adefovir Dipivoxil with full CTD Dossier and COPP support. Our logistics network ensures secure transit to Vietnam, Nigeria, Uzbekistan, and the Philippines, providing WHO-GMP quality at competitive B2B prices.

Commercial Inquiries

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in