In the pharmaceutical industry, Adrenochrome Monosemicarbazone tablets (often available in 10 mg or 25 mg, also known as Carbazochrome) are specialized hemostatic agents. As a pharmacist, I classify this molecule as a capillary-stabilizing agent used to control bleeding by increasing microvascular resistance without affecting blood coagulation parameters like pressure or heart rate.
Primary Clinical Uses
-
Capillary Hemorrhage Control: Used to prevent and treat systemic bleeding arising from capillary fragility or increased permeability.
-
Surgical Prophylaxis: Often administered pre-operatively or post-operatively to reduce blood loss in surgeries involving areas rich in capillaries (e.g., tonsillectomy, adenoidectomy, or dental extractions).
-
Hematuria and Epistaxis: Indicated for the management of idiopathic hematuria (blood in urine) and persistent epistaxis (nosebleeds).
-
Retinal Hemorrhage: Sometimes used in ophthalmology to manage small vessel bleeding in the retina, often associated with diabetes or hypertension.
-
Mechanism of Action
Adrenochrome Monosemicarbazone works by acting directly on the capillary walls. It promotes the contraction of microvessels and increases the resistance of the capillary basement membrane. By reducing capillary permeability and increasing “capillary fragility resistance,” it shortens bleeding time without inducing systemic vasoconstriction or interfering with the natural clotting cascade (fibrinogen to fibrin conversion).
The Manufacturer’s Perspective: Formulation & Export
From a manufacturing and global trading standpoint, Adrenochrome Monosemicarbazone is a niche but essential product for surgical and emergency care:
-
Formulation Stability: Being an oxidation product of adrenaline, the stability of the monosemicarbazone derivative is critical. As a WHO-GMP manufacturer, we utilize optimized excipient profiles to ensure the molecule remains stable and effective under various storage conditions.
-
Synergistic Combinations: We often see high B2B demand for this molecule in combination with other hemostatics or as a standalone tablet for clinics and hospitals.
-
Global Market Demand: There is a consistent demand for reliable hemostatics in emerging markets for trauma centers and surgical units. Our Mumbai-based export hub is equipped to supply this to B2B partners across Africa, Southeast Asia, and the Middle East.
-
Documentation Excellence: We provide full CTD Dossiers and technical data sheets to support international registration, ensuring compliance with local health authority standards.