In the pharmaceutical industry, Mefenamic Acid (brand name Ponstan 500mg) is a non-steroidal anti-inflammatory drug (NSAID) of the fenamate class. As a pharmacist and manufacturer, I view this as a specialized analgesic that is particularly effective for pain associated with the smooth muscle, such as the uterus and digestive tract.
At your WHO-GMP facility in Mumbai, where you focus on high-quality manufacturing and international exports, understanding the unique clinical profile of Mefenamic Acid—such as its dual action on receptors—is a significant advantage for your B2B marketing.
Primary Clinical Indications
Mefenamic Acid is primarily used for the short-term management of mild to moderate pain:
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Primary Dysmenorrhea: This is its most common and effective use. It targets the underlying cause of severe period pain and excessive bleeding (menorrhagia).
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Musculoskeletal Pain: Used for joint pain, rheumatoid arthritis, osteoarthritis, and muscle injuries.
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Dental Pain: Often prescribed following dental procedures to reduce swelling and throbbing.
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Post-Operative Pain: Management of pain after surgery, provided it is not heart-related (see warnings below).
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Fever: Effective in reducing temperature in children (over 14 years) and adults during flu-like illnesses.
Mechanism: The Dual-Action Fenamate
Mefenamic Acid works differently than some other NSAIDs because it targets pain through two distinct pathways:
Enzyme Inhibition: It inhibits the COX-1 and COX-2 enzymes, which prevents the production of new prostaglandins (the chemicals responsible for pain and inflammation).
Receptor Blockade: Uniquely, Mefenamic Acid also blocks the EP (prostanoid) receptors themselves. This means it doesn’t just stop the body from making pain signals; it also prevents any already-formed prostaglandins from sending their signal to the brain.
Smooth Muscle Relaxation: This dual action is why it is exceptionally effective at relaxing the smooth muscles of the uterus during menstruation.
The Pharmacist’s “Technical Warning”
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The 7-Day Limit: Mefenamic Acid is strictly for short-term use. For general pain, it should not be taken for more than 7 days; for menstrual pain, 2 to 3 days is the standard.
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GI Safety: Like all NSAIDs, it carries a risk of stomach ulcers and bleeding. It must be taken with food or milk to protect the gastric mucosa.
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Contraindications: It should not be used in patients with active stomach ulcers, inflammatory bowel disease (Crohn’s or Colitis), severe heart, liver, or kidney failure.
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Asthma Sensitivity: Patients with “Aspirin-sensitive asthma” should avoid this drug, as it can trigger severe bronchospasms.
The Manufacturer’s Perspective: Technical & Export
From a production and B2B standpoint at your facility in Mumbai:
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The “Fenamate” USP: On your marketplace, emphasize that Mefenamic Acid has superior efficacy for gynecological pain compared to Ibuprofen or Naproxen due to its receptor-blocking capabilities.
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Stability for Export: Mefenamic Acid is a stable, off-white crystalline powder with a high melting point (230°C), making it robust for tropical storage. For Zone IVb export, utilizing Alu-Alu blister packaging ensures it remains protected from the high humidity found in SE Asia and Africa.
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Dossier Support: We provide full CTD/eCTD Dossiers to support your firm in bidding for international health tenders and registering your product in emerging markets.