In the pharmaceutical industry, Cetirizine Hydrochloride 10 mg is a potent, second-generation receptor antagonist. As a pharmacist, I classify Cetirizine as a “non-sedating” antihistamine—though technically, it is “low-sedating” compared to first-generation drugs. Its primary value in a product portfolio lies in its rapid onset of action and its high selectivity for peripheral histamine receptors.
Primary Clinical Uses
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Allergic Rhinitis: Effectively relieves symptoms of hay fever and seasonal allergies, including sneezing, rhinorrhea (runny nose), and post-nasal drip.
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Chronic Urticaria (Hives): It is a frontline treatment for chronic idiopathic urticaria, reducing the number, size, and itching of wheals.
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Allergic Conjunctivitis: Manages ocular symptoms such as redness, itching, and watering of the eyes caused by environmental allergens.
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Dermatological Allergies: Often used as an adjunct to treat pruritus (itching) associated with insect bites or contact dermatitis.
Mechanism of Action
Cetirizine works by selectively inhibiting peripheral $H_1$ receptors. When an allergen enters the body, mast cells release histamine, which binds to $H_1$ receptors and causes vasodilation, increased capillary permeability, and itching.
Cetirizine competes with free histamine for binding sites on these receptors. Unlike first-generation antihistamines (like Chlorpheniramine), Cetirizine has poor penetration across the Blood-Brain Barrier (BBB), which is why it causes significantly less drowsiness while maintaining high peripheral efficacy.
The Manufacturer’s Perspective: Formulation & Export
From a manufacturing and global trade standpoint, Cetirizine is a high-volume OTC and prescription staple:
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API Purity & Stability: As a WHO-GMP manufacturer, we ensure the Cetirizine HCl API meets stringent BP/USP/IP monographs, specifically monitoring for the “Related Substance A” impurity to ensure safety and shelf-life.
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Formulation Versatility: We manufacture Cetirizine in various formats, including film-coated tablets, chewable tablets for pediatrics, and oral syrups. For the 10 mg tablets, we focus on a small, easy-to-swallow “breakline” design.
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Packaging for Global Markets: To protect against the hygroscopic nature of the salt, we utilize PVC/PVDC or Alu-Alu blister packaging. This ensures the product remains stable for 24–36 months in Zone IVb (hot and humid) climates.
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B2B & Tender Supply: Cetirizine is a core item for international B2B distributors. Our Mumbai-based facility provides complete CTD/eCTD Dossiers for rapid registration in global markets.