In the pharmaceutical industry, Albendazole tablets (commonly 400 mg) are a broad-spectrum anthelmintic agent belonging to the benzimidazole class. As a pharmacist, I view Albendazole as an essential “essential medicine” (as per WHO) due to its high efficacy in eradicating a wide range of systemic and intestinal parasitic infestations.
Primary Clinical Uses
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Intestinal Nematode Infections: The gold standard for treating common helminthic infections such as Roundworm (Ascaris lumbricoides), Hookworm, Whipworm, and Pinworm.
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Neurocysticercosis: Indicated for the treatment of parenchymal neurocysticercosis caused by larval forms of the pork tapeworm (Taenia solium).
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Hydatid Disease: Used to treat cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm (Echinococcus granulosus).
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Giardiasis: Often used as an alternative or adjunct treatment for pediatric giardiasis.
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Mass Drug Administration (MDA): Frequently used in global health programs for the deworming of school-aged children to improve nutritional and cognitive health.
Mechanism of Action
Albendazole works by causing selective degeneration of the cytoplasmic microtubules in the intestinal and tegumental cells of intestinal helminths and larvae. It binds to the colchicine-sensitive site of beta-tubulin, inhibiting its polymerization. This disruption leads to the depletion of glycogen stores, failure of glucose uptake, and the eventual death of the parasite due to energy depletion.
The Manufacturer’s Perspective: Formulation & Export
From a manufacturing and global trade standpoint, Albendazole 400 mg is one of the highest-volume products for international pharmaceutical firms:
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Chewable Formulations: Since Albendazole is often used in pediatric populations, formulating it as a fruity-flavored chewable tablet is critical for patient compliance and ensures the drug is properly crushed before swallowing for maximum absorption.
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Solubility Challenges: Albendazole is poorly soluble in water. As a WHO-GMP manufacturer, we utilize specific micronization techniques to ensure consistent particle size, which directly influences the drug’s dissolution and bioavailability.
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Global Health Tenders: This product is a staple for international NGOs, UNICEF, and government health departments. Our Mumbai hub is optimized for the high-capacity production required for these large-scale tenders.
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Regulatory Readiness: We provide comprehensive CTD/eCTD Dossiers to support B2B partners in registering the product across diverse markets in Africa, Southeast Asia, and Latin America.