In the pharmaceutical industry, Ranitidine Hydrochloride 150 mg is a classic $H_2$-receptor antagonist ($H_2$ blocker). While the proton pump inhibitor (PPI) class has become more common, Ranitidine remains a preferred choice for many due to its rapid onset of action and its specific effectiveness in controlling “nocturnal acid breakthrough.”

Primary Clinical Uses

• GERD (Gastroesophageal Reflux Disease): Relief of heartburn and acid indigestion.

• Peptic Ulcer Disease: Treatment and maintenance of gastric and duodenal ulcers.

• Zollinger-Ellison Syndrome: Management of pathological hypersecretory conditions where the stomach produces extreme amounts of acid.

• Prophylaxis of Aspiration Pneumonitis: Given before surgery to reduce the acidity of gastric contents, protecting the lungs during anesthesia.

• Erosive Esophagitis: Healing and relief of pain from acid-damaged esophageal lining.

Mechanism of Action: Competitive $H_2$ Blockade

Ranitidine works by selectively blocking the histamine receptors located on the parietal cells in the stomach lining.

Histamine Inhibition: Histamine is one of the primary triggers for acid production. Ranitidine competes with histamine for $H_2$ receptors.

Reduction of Basal Acid: It is particularly effective at reducing “basal” acid secretion (the acid produced when the stomach is empty), which is why it is often taken at bedtime.

Volume & Acidity Reduction: It reduces both the total volume of gastric juice and the concentration of hydrogen ions (acidity).

The Manufacturer’s Perspective: Technical & Regulatory

From a production and global trade standpoint at your WHO-GMP facility in Mumbai, there are critical technical aspects to consider for this molecule:

• The NDMA Context: As a pharmacist and firm owner, you are aware of the global regulatory history regarding NDMA (N-Nitrosodimethylamine) impurities in Ranitidine. For your digital platform, emphasizing “NDMA-Free Certified API” and rigorous stability testing is the single most important factor for building B2B trust and securing export contracts.

• tability & Storage: Ranitidine is sensitive to moisture and light. At our facility, we utilize Alu-Alu blister packaging to ensure the 150 mg dose maintains its integrity for 36 months, even in Zone IVb climates.

• Formulation Versatility: While 150 mg is the standard, manufacturing a 75 mg OTC strength and a 300 mg intensive strength allows your trading firm to cover both the retail and hospital segments.

• Dossier Support: Despite regulatory shifts, there is still high demand for Ranitidine in many international markets. We provide full CTD/eCTD Dossiers with updated impurity profiling to support your export registrations.