Healthy Inc > Blog > treatment of EPS and Parkinsonism
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How does Biperiden work in the body?

In the pharmaceutical industry, Biperiden is a synthetic anticholinergic agent with high selectivity for the central nervous system. As a pharmacist and manufacturer, I classify this as a frontline treatment for Parkinson’s disease and, more importantly in the generic export market, for the management of Drug-Induced Extrapyramidal Symptoms (EPS).

At your WHO-GMP facility in Mumbai, you likely handle this as Biperiden Hydrochloride (2 mg tablets) or Biperiden Lactate (injectable), which is a staple for psychiatric clinics worldwide.

Mechanism of Action: Restoring the Neurochemical Balance

Biperiden works by correcting a specific imbalance in the brain’s “motor control center” (the striatum).

  • The Dopamine-Acetylcholine Seesaw: In a healthy brain, dopamine (which inhibits movement) and acetylcholine (which excites movement) are in balance. In Parkinson’s or when taking antipsychotics, dopamine levels drop or are blocked.

  • Relative Cholinergic Overactivity: When dopamine goes down, acetylcholine becomes relatively too high. This “hyper-cholinergic” state causes the tremors, muscle rigidity, and spasms (dystonia) associated with EPS.

  • Muscarinic Blockade: Biperiden is a competitive antagonist at peripheral and central muscarinic receptors (primarily $M_1$). By blocking these receptors, it “turns down” the excessive excitatory signals of acetylcholine, restoring the balance and smoothing out muscle movements.

Primary Clinical Applications

  • Antipsychotic Side Effects: It is the “gold standard” for reversing acute dystonic reactions (muscle spasms of the neck/eyes) caused by older antipsychotics like Haloperidol.

  • Parkinsonism: Reduces muscle rigidity and akinesia (difficulty starting movement) in early-stage Parkinson’s disease.

  • Nicotine Antagonism: Emerging research suggests it may also act on nicotinic receptors, though its primary action remains muscarinic.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai, Biperiden is a high-precision specialty product:

  • The Injectable USP: While tablets are common, your Biperiden Lactate 5 mg/ml Injection is a critical “Emergency Room” product. Highlighting the rapid onset of action (within minutes) on your digital platforms is a major selling point for hospital supply chains.

  • Stability for Export: Biperiden is sensitive to light. At our facility, we utilize Amber-colored ampoules for injections and Alu-Alu blister packaging for tablets to ensure a 36-month shelf life, which is vital for export to Zone IVb tropical regions.

  • Niche Market Advantage: Biperiden is not as “crowded” as molecules like Paracetamol. By focusing on this specialty CNS (Central Nervous System) drug on your multivendor marketplace, you can attract high-value, specialized medical distributors.

  • Dossier Support: We provide full CTD/eCTD Dossiers to support your firm’s registration in regulated markets, ensuring your brand stands out for its technical and regulatory compliance.

    https://healthyinc.co.in/product/biperiden-tablets/

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What is Trihexyphenidyl Hydrochloride Benzhexol?

In the pharmaceutical industry, Trihexyphenidyl Hydrochloride (also known as Benzhexol Hydrochloride) is a potent synthetic antimuscarinic agent. As a pharmacist and manufacturer, I classify this as a frontline treatment for Parkinsonism and, more commonly in the generic market, for managing the side effects of antipsychotic medications.

At your WHO-GMP facility in Mumbai, you likely handle this as 2 mg or 5 mg tablets, which are critical components of neuropsychiatric healthcare.

Primary Clinical Uses

  • Parkinson’s Disease: Used as an adjunct to Levodopa to reduce muscular rigidity and “resting tremors.”

  • Extrapyramidal Symptoms (EPS): This is its most common use in modern medicine—treating the “shaking” or “stiffness” (drug-induced parkinsonism) caused by antipsychotic drugs like Haloperidol or Chlorpromazine.

    Dystonia: Used to treat involuntary muscle contractions and abnormal postures.

Mechanism of Action: The Acetylcholine Balance

Trihexyphenidyl works by restoring the chemical balance in the basal ganglia of the brain.

Dopamine-Acetylcholine Balance: In Parkinsonism or when taking antipsychotics, dopamine levels are low, causing a relative “overactivity” of Acetylcholine.

Competitive Inhibition: Trihexyphenidyl acts as a competitive antagonist at M1 muscarinic receptors.

Antispasmodic Effect: By blocking acetylcholine, it relaxes smooth muscles and inhibits the parasympathetic nervous system, effectively “calming” the tremors and muscle stiffness.

Technical Profile for the Pharmacist

As a professional in the field, there are two technical nuances you should highlight on your digital platforms:

  • Anticholinergic “Side Effect Profile”: Because it blocks acetylcholine systemically, it causes “Dry Mouth,” “Blurred Vision,” and “Constipation.” In your Product Information Leaflet (PIL), advising patients to maintain oral hygiene is a mark of a professional manufacturer.

  • Tapering Necessity: Similar to other neuro-active drugs, it should not be stopped abruptly to avoid “rebound” parkinsonian symptoms.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai, here is how to position Benzhexol for your marketplace:

  • The “Combo-Kit” Strategy: Many B2B buyers in the psychiatric space look for “kits.” Promoting Benzhexol alongside your antipsychotic range (like Olanzapine or Risperidone) is a smart cross-selling strategy for your multivendor marketplace.

  • Stability & Micronization: Trihexyphenidyl is a low-dose drug (2 mg). At our facility, we ensure high-precision micronization and blend uniformity so that every tablet contains the exact dose. Highlighting this “Batch-to-Batch Consistency” is a major USP for international auditors.

  • Packaging for Export: We utilize Alu-Alu or PVC/PVDC blister packaging to ensure a 36-month shelf life, even in the high-humidity climates of Zone IVb regions like Africa and Southeast Asia.

  • Dossier Readiness: We provide full CTD/eCTD Dossiers for both 2 mg and 5 mg strengths, supporting your firm in bidding for government mental health tenders.

Trihexyphenidyl Hydrochloride Tablets

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