Healthy Inc > Blog > Roxithromycin BP/USP/IP
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What is Roxid 150 mg used for?

In the pharmaceutical industry, Roxid 150 mg is a prominent brand of Roxithromycin, a semi-synthetic Macrolide antibiotic. As a pharmacist and manufacturer, I view it as an evolved alternative to Erythromycin, offering superior acid stability and a longer half-life, which allows for convenient twice-daily dosing.

At your WHO-GMP facility in Mumbai, Roxithromycin 150 mg is a high-value export SKU, particularly for respiratory and ENT (Ear, Nose, Throat) portfolios in international B2B markets.

Primary Clinical Indications

  • Respiratory Tract Infections (RTIs): Highly effective against community-acquired pneumonia, acute bronchitis, and tonsillitis.

  • ENT Infections: Used for sinusitis and otitis media (middle ear infections).

  • Skin and Soft Tissue Infections: Treatment of boils, folliculitis, and impetigo.

  • Genital Infections: Used for non-gonococcal urethritis caused by Chlamydia.

  • Odontogenic Infections: Management of dental infections when beta-lactam antibiotics cannot be used.

Mechanism: Protein Synthesis Inhibition

Roxithromycin does not kill bacteria by breaking the cell wall; instead, it “starves” them of the proteins they need to replicate.

Ribosomal Binding: It binds reversibly to the 50S subunit of the bacterial ribosome.

Translocation Blockade: This binding prevents the translocation of peptides, effectively stopping the synthesis of new proteins.

Bacteriostatic Action: By halting growth and replication, it allows the human immune system to eliminate the remaining bacteria.

The Pharmacist’s “Technical Warning”

  • The “Empty Stomach” Advantage: For maximum absorption, Roxithromycin should technically be taken at least 15 minutes before a meal.

  • Drug Interactions: Like most macrolides, it can interact with Theophylline and Ergot alkaloids (used for migraines). Advise patients to check their current medications.

  • Liver Caution: Use with care in patients with hepatic impairment, as the drug is primarily metabolized in the liver.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai:

  • The “Acid Stability” USP: On your marketplace, highlight that Roxithromycin is acid-stable. Unlike Erythromycin, it does not break down in gastric acid, leading to higher bioavailability and significantly fewer GI side effects like stomach cramping.

  • Stability for Export: Roxithromycin is stable but sensitive to high humidity. Utilizing Alu-Alu blister packaging is the gold standard for maintaining a 36-month shelf life in Zone IVb tropical regions.

  • Dossier Support: We provide full CTD/eCTD Dossiers to support your firm’s registration in international health tenders and for building a strong anti-infective portfolio.

Roxithromycin Tablets

Posted on:

What is Roxithromycin 150 mg used for?

In the pharmaceutical industry, Roxithromycin 150 mg is a semi-synthetic Macrolide antibiotic. As a pharmacist and manufacturer, I classify this as a “Second-Generation Macrolide.” It was developed to overcome the limitations of Erythromycin, offering better acid stability, a longer half-life, and significantly fewer gastrointestinal side effects.

Primary Clinical Uses

  • Respiratory Tract Infections (RTIs): Highly effective for both upper and lower RTIs, including acute pharyngitis, tonsillitis, sinusitis, and community-acquired pneumonia.

  • Skin and Soft Tissue Infections: Used for treating boils, carbuncles, folliculitis, and impetigo.

  • Urogenital Infections: Effective against certain non-gonococcal urethritis, particularly those caused by Chlamydia and Mycoplasma.

  • Odontogenic Infections: Frequently prescribed for dental abscesses and gum infections.

  • ENT Infections: A staple for Otitis Media (middle ear infections) in patients allergic to Penicillins.

Mechanism of Action: Inhibition of Protein Synthesis

Roxithromycin is primarily bacteriostatic, meaning it prevents bacteria from growing rather than killing them outright (though it can be bactericidal at high concentrations).

Ribosomal Binding: The drug binds reversibly to the 50S subunit of the bacterial ribosome.

Translocation Blockade: It specifically blocks the translocation step, where the growing peptide chain moves along the ribosome.

Protein Synthesis Inhibition: By stopping the assembly of essential proteins, the bacteria can no longer replicate or maintain their cellular functions.

High Tissue Concentration: Unlike many other antibiotics, Roxithromycin achieves very high concentrations inside macrophages and neutrophils, which then carry the drug directly to the site of infection (the “Trojan Horse” effect).

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your WHO-GMP facility in Mumbai, Roxithromycin 150 mg is a strategic product:

  • Acid Stability: Unlike Erythromycin, Roxithromycin is stable in gastric acid. This means we do not necessarily need expensive enteric coating, allowing for a more cost-effective film-coated tablet that still maintains high bioavailability.

  • The 150 mg Dosage: This is the standard adult dose, typically taken twice daily. For your digital platform, highlighting the BID (twice a day) dosing compared to the QID (four times a day) dosing of older macrolides is a major USP for patient compliance.

  • Stability & Packaging: Roxithromycin is stable but should be protected from extreme heat. We utilize Alu-Alu or high-grade PVC/PVDC blisters to ensure a 36-month shelf life for export to Zone IVb regions.

  • Dossier Support: This molecule is widely used in Southeast Asia, the Middle East, and Africa. Our Mumbai facility provides full CTD/eCTD Dossiers to support your international registration and trading efforts.

Roxithromycin Tablets

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