In the pharmaceutical industry, Praziquantel 600 mg is the “gold standard” anthelminthic (anti-parasitic) medication specifically designed to target trematodes (flukes) and cestodes (tapeworms).

As a pharmacist and manufacturer, I view Praziquantel as one of the most essential medicines in global health. It is the primary weapon used in mass drug administration (MDA) programs to combat tropical parasitic diseases.

Primary Clinical Uses

• Schistosomiasis (Bilharzia): This is the primary use case. It treats infections caused by all species of Schistosoma (blood flukes).

• Liver Flukes: Effective against Clonorchis sinensis (Chinese liver fluke) and Opisthorchis viverrini.

• Lung Flukes: Used to treat Paragonimus westermani.

• Tapeworm Infections (Cestodes): Used for intestinal tapeworms (like Taenia saginata or Taenia solium) and is the drug of choice for Neurocysticercosis (parasitic cysts in the brain).

Mechanism of Action: The Calcium Influx

Praziquantel works by causing a rapid and lethal change in the parasite’s cell membrane.

Membrane Permeability: It increases the permeability of the parasite’s cell membranes to calcium ions ($Ca^{2+}$).

Tetanic Contraction: This sudden influx of calcium causes massive, immediate contraction (paralysis) of the worm’s muscles.

Integumentary Damage: The drug causes the parasite’s outer “skin” (integument) to vacuolize and disintegrate.

Phagocytosis: Once the protective skin is damaged, the parasite is easily attacked and digested by the host’s own immune system (white blood cells).

The Manufacturer’s Perspective: Formulation & Export

From a production standpoint at your WHO-GMP facility in Mumbai, Praziquantel 600 mg presents unique technical challenges and opportunities:

• The “Bitter API” Challenge: Praziquantel has an extremely bitter, metallic taste that can cause gagging. As a manufacturer, we utilize high-quality film-coating or sugar-coating to ensure the 600 mg tablet is palatable. Highlighting “Taste-Masked Technology” on your digital platform is a major B2B selling point.

• Scoring for Dosing: Praziquantel dosing is usually weight-based ($40\text{–}60\text{ mg/kg}$). Therefore, the 600 mg tablet must be manufactured with triple-scoring (three deep break lines) to allow the tablet to be split into 150 mg segments for accurate pediatric dosing.

• BCS Class II (Solubility): It has low water solubility. Our QC lab ensures that the dissolution profile meets USP standards to ensure maximum bioavailability once ingested.

• Global Tenders: Because this is on the WHO Model List of Essential Medicines, it is a high-volume item for UN and NGO tenders (like UNICEF or USAID). Our Mumbai facility provides the full eCTD Dossiers needed for these massive international contracts.https://healthyinc.co.in/product/praziquantel-tablets