In the pharmaceutical industry, Trypsin-Chymotrypsin (100,000 AU) is a widely utilized proteolytic enzyme combination for managing post-operative edema and inflammation. As a pharmacist and manufacturer, I view the pricing of this molecule as highly competitive, with significant variance between legacy brands and newer generic entries.

At your WHO-GMP facility in Mumbai, this SKU represents a high-volume opportunity, especially when positioned as a cost-effective alternative to market leaders like Chymoral Forte.

Market Pricing Analysis (Current 2026)

The price of a Trypsin-Chymotrypsin 100,000 AU tablet depends on the brand, packaging size, and whether it is a branded generic or a pure generic.

B2B Bulk Pricing: For manufacturing and trading firms, bulk procurement prices on platforms like IndiaMART range from ₹135 to ₹400 per box (typically 10×10 or 10×20 tablets), depending on the volume and manufacturer.

Technical Specification & Mechanism

• Composition: A synergistic blend of Trypsin and Chymotrypsin in a 6:1 ratio, providing a total enzymatic activity of 100,000 Armour Units (AU).

• Formulation: These are almost exclusively Enteric-Coated tablets. This is critical because the enzymes are proteins that would otherwise be denatured by stomach acid before reaching the site of absorption in the small intestine.

• Mechanism: It works by breaking down fibrin clots and decreasing capillary permeability. This improves local blood circulation and facilitates the rapid “drainage” of inflammatory fluid (edema) from the injured tissue.

The Pharmacist’s “Technical Warning”

• The “Empty Stomach” Rule: For maximum systemic absorption, the tablet must be taken 30 minutes before a meal. Taking it with food will cause the enzymes to digest the dietary protein instead of being absorbed into the bloodstream.

   

• Surgery Precaution: Advise patients to stop taking the medication at least 2 weeks before a scheduled surgery, as it can interfere with normal blood clotting mechanisms.

• Contraindications: Use with extreme caution in patients with severe liver or kidney impairment or those with pre-existing blood clotting disorders.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai:

• The “Enteric Coating” USP: On your digital marketplace, emphasize the quality of your enteric coating. High-quality polymers ensure the API reaches the duodenum intact, which is the primary factor in clinical efficacy.

• Stability for Export: Proteolytic enzymes are sensitive to high temperatures. For export to Zone IVb tropical regions (Africa/SE Asia), Alu-Alu blister packaging is essential to prevent moisture ingress and maintain enzymatic activity for a 36-month shelf life.

• Dossier Support: We provide full CTD/eCTD Dossiers to support your firm’s registration in international surgical and trauma care tenders.