In the pharmaceutical industry, Allopurinol tablets (commonly 100 mg and 300 mg) are the gold standard in xanthine oxidase inhibitor therapy. As a pharmacist, I view Allopurinol as a foundational chronic care medication designed not just to treat symptoms, but to chemically recalibrate the body’s uric acid production cycle.

Primary Clinical Uses

• Gout Management: Used for the long-term prevention of gouty arthritis and the reduction of tophi (uric acid crystal deposits) by lowering serum urate levels.

• Urate Nephropathy: Prevents the formation of uric acid kidney stones and protects renal function in patients with high urate excretion.

• Tumor Lysis Syndrome (TLS): Critically used in oncology to prevent acute hyperuricemia in patients undergoing chemotherapy for leukemia or lymphoma.

• Recurrent Calcium Oxalate Stones: Indicated for patients with recurrent calcium stones who also exhibit high levels of uric acid in their urine.

• Mechanism of Action

Allopurinol is a structural analogue of the natural purine base, hypoxanthine. It acts by inhibiting the enzyme xanthine oxidase, which is responsible for the conversion of hypoxanthine to xanthine and subsequently xanthine to uric acid. By blocking this enzymatic pathway, Allopurinol reduces the concentration of uric acid in both the blood and urine without interfering with the biosynthesis of vital purines.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing and global trade standpoint, Allopurinol is a high-demand, high-stability molecule that fits perfectly into an export-oriented portfolio:

• Dosage Versatility: We manufacture both 100 mg (for titration) and 300 mg (for maintenance) strengths to ensure flexible clinical dosing for patients with varying degrees of renal clearance.

• Pharmacopeial Compliance: Our tablets are manufactured to meet BP/USP/IP standards, ensuring consistent dissolution profiles and high purity levels to minimize the risk of hypersensitivity reactions.

• Stability for Export: Allopurinol is a robust molecule. As a WHO-GMP certified manufacturer, we ensure our formulations are stable in Zone IVb conditions, making them ideal for long-transit exports to Africa, Southeast Asia, and the CIS region.

• B2B & Tender Supply: Given its inclusion in the WHO Model List of Essential Medicines, Allopurinol is a primary item for government health tenders and international B2B pharmaceutical marketplaces.