Healthy Inc > Blog > Ciprofloxacin Hydrochloride manufacturer
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What is Ciprofloxacin 100mg used for?

In the pharmaceutical industry, Ciprofloxacin 100 mg is a second-generation fluoroquinolone antibiotic. As a pharmacist, I view this specific low-strength dosage as a targeted therapeutic tool, primarily utilized in pediatric care or for very specific, uncomplicated adult infections where higher doses (250 mg or 500 mg) are not clinically necessary.

Primary Clinical Uses

  • Uncomplicated Urinary Tract Infections (UTIs): Frequently used for short-course treatment of acute, uncomplicated cystitis in women.

  • Pediatric Applications: Used to treat complicated UTIs and pyelonephritis in children (ages 1-17), where the dosage is strictly weight-based.

  • Post-Exposure Inhalation Anthrax: Part of the prophylactic regimen for children and adults following exposure to Bacillus anthracis.

  • Cystic Fibrosis: Management of pulmonary exacerbations caused by Pseudomonas aeruginosa in pediatric patients.

  • Gonorrhea: Though resistance has limited its use, it was historically used as a single 100 mg dose for uncomplicated urethral and endocervical infections.

Mechanism of Action

Ciprofloxacin is a rapidly bactericidal agent. It works by inhibiting two essential bacterial enzymes: DNA Gyrase (Topoisomerase II) and Topoisomerase IV.

By targeting these enzymes, Ciprofloxacin prevents the bacteria from “unzipping” and repairing their DNA during replication. This leads to irreversible DNA damage and rapid bacterial cell death. Its broad-spectrum activity is particularly effective against Gram-negative pathogens like E. coli and Pseudomonas.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing and global trade standpoint, Ciprofloxacin 100 mg requires precise quality controls:

  • API Purity: As a WHO-GMP manufacturer, we ensure the Ciprofloxacin Hydrochloride API meets strict BP/USP/IP standards, specifically monitoring for the “Ethylenediamine” impurity.

  • Taste Masking: Ciprofloxacin is extremely bitter. We utilize advanced film-coating technology to ensure the 100 mg tablet is palatable, especially given its frequent use in adolescent and pediatric populations.

  • Stability for Global Trade: Ciprofloxacin is light-sensitive. We utilize Alu-Alu or opaque PVC/PVDC blister packaging to maintain its 36-month shelf life during export to hot and humid Zone IVb regions (Africa and Southeast Asia).

  • B2B & Tender Supply: This strength is a staple for pediatric hospital tenders and international NGOs. Our Mumbai facility provides full CTD/eCTD Dossiers to support rapid registration for our B2B partners.

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What is Ciprofloxacin 250mg used for?

In the pharmaceutical industry, Ciprofloxacin 250 mg is a broad-spectrum second-generation fluoroquinolone antibiotic. As a pharmacist, I classify it as a “workhorse” antibiotic due to its exceptional tissue penetration and high efficacy against Gram-negative pathogens, particularly Enterobacteriaceae.

Primary Clinical Uses

  • Urinary Tract Infections (UTIs): Often used for both uncomplicated and complicated UTIs, including cystitis and pyelonephritis.

  • Respiratory Tract Infections: Effective against acute sinusitis and certain types of pneumonia, especially those involving Gram-negative bacteria.

  • Gastrointestinal Infections: A frontline treatment for “traveler’s diarrhea” (caused by E. coli), typhoid fever (Salmonella Typhi), and shigellosis.

  • Skin and Bone Infections: Used for osteomyelitis and skin structure infections caused by susceptible organisms.

  • Anthrax Prophylaxis: Specifically indicated for post-exposure prophylaxis of inhalational anthrax.

Mechanism of Action

Ciprofloxacin acts by inhibiting the bacterial enzymes DNA gyrase (Topoisomerase II) and Topoisomerase IV. These enzymes are essential for the replication, transcription, and repair of bacterial DNA.

By interfering with these processes, Ciprofloxacin causes double-stranded breaks in the bacterial DNA, leading to rapid cell death. It is a bactericidal antibiotic, meaning it kills the bacteria rather than just inhibiting their growth.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing and global trade standpoint, Ciprofloxacin is a staple of any anti-infective portfolio:

  • Solubility and Bioavailability: Ciprofloxacin HCl is highly soluble. As a WHO-GMP manufacturer, we focus on optimized disintegration times to ensure rapid absorption, typically reaching peak plasma concentrations within 1–2 hours.

  • Taste Masking: The API is intensely bitter. We utilize advanced film-coating technology to ensure the 250 mg tablets are palatable and easy to swallow, which is critical for patient compliance.

  • Packaging for Stability: Ciprofloxacin can be sensitive to light. We use PVC/PVDC or Alu-Alu blister packaging to ensure a 36-month shelf life, especially for export to Zone IVb climates (Africa, SE Asia).

  • B2B and Tender Volume: Because it is on the WHO Model List of Essential Medicines, it is a high-volume item for international health tenders. Our Mumbai-based facility provides full CTD/eCTD Dossier support for registration across global markets.

 

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