Healthy Inc > Blog > Calcium 500mg D3 250IU
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What is Elemental Calcium and vitamin D3 used for?

In the pharmaceutical industry, the combination of Elemental Calcium and Vitamin D3 (Cholecalciferol) is the foundational therapy for bone mineral density management and systemic calcium homeostasis.

As a pharmacist and manufacturer, I classify this as a Mineral and Vitamin Supplement. At your WHO-GMP facility in Mumbai, you likely manufacture this in various strengths, most commonly 500 mg Elemental Calcium paired with 250 IU or 400 IU of Vitamin D3.

Primary Clinical Uses

  • Osteoporosis Management: Used to increase bone density and reduce fracture risk in elderly patients and post-menopausal women.

  • Hypocalcemia: Treatment of low blood calcium levels caused by parathyroid disorders or dietary deficiencies.

  • Osteomalacia & Rickets: Used to reverse the “softening of bones” caused by severe Vitamin D deficiency in adults and children.

  • Prenatal Support: Frequently prescribed during pregnancy to support the skeletal development of the fetus and prevent the depletion of maternal bone stores.

  • Adjuvant Therapy: Often paired with bisphosphonates or hormone replacement therapy (HRT) for comprehensive bone care.

Mechanism: The Absorption Synergy

The reason these two are combined into a single tablet is a matter of biological necessity. Calcium cannot be utilized effectively by the body without the presence of Vitamin D3.

Vitamin D3 (The Gatekeeper): Once ingested, Vitamin D3 is converted in the liver and then the kidneys to its active form, Calcitriol. Calcitriol stimulates the synthesis of calcium-binding proteins (calbindin) in the small intestine.

Elemental Calcium (The Building Block): “Elemental” refers to the actual weight of the calcium available for absorption (e.g., Calcium Carbonate is 40% elemental calcium). Once absorbed, it is deposited into the bone matrix.

The Result: Together, they maintain Calcium Homeostasis, ensuring the body doesn’t have to “steal” calcium from the bones to support vital nerve and muscle functions.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai, there are several ways to optimize this product for your digital platforms:

  • Calcium Source Transparency: On your marketplace, specify whether you use Calcium Carbonate (highest elemental yield, 40%) or Calcium Citrate (better absorbed in patients with low stomach acid). This technical detail is a major USP for B2B buyers.

  • The “Chewable” Factor: For the geriatric and pediatric markets, offering chewable flavored tablets is a significant selling point. It improves patient compliance for those who have difficulty swallowing large, high-density tablets.

  • Stability & Oxidation: Vitamin D3 is highly sensitive to light and oxidation. At our facility, we utilize Alu-Alu blister packaging or opaque HDPE bottles with induction sealing to ensure a 36-month shelf life. This is critical for export to tropical Zone IVb regions.

  • Dossier Readiness: As a staple of “Essential Medicine” lists, we provide full CTD/eCTD Dossiers to support your firm in bidding for government health tenders and hospital supply contracts globally.

Calcium Carbonate with Vitamin D3 Tablets

Posted on:

What is Elemental Calcium and vitamin D3 tablets used for?

In the pharmaceutical industry, the combination of Elemental Calcium and Vitamin D3 (Cholecalciferol) is the foundational therapy for bone mineral density management.

As a pharmacist and manufacturer, I classify this as a Mineral and Vitamin Supplement. At your WHO-GMP facility in Mumbai, you likely manufacture this in various strengths, most commonly 500 mg Elemental Calcium with 250 IU or 400 IU of Vitamin D3.

Primary Clinical Uses

  • Osteoporosis Management: Used to increase bone density and reduce the risk of fractures in elderly patients and post-menopausal women.

  • Hypocalcemia: Treatment of low blood calcium levels caused by parathyroid issues or poor diet.

  • Osteomalacia & Rickets: Used to reverse the “softening of bones” caused by severe Vitamin D deficiency.

  • Prenatal Support: Often prescribed during pregnancy to support the skeletal development of the fetus and maintain maternal bone health.

  • Adjuvant Therapy: Frequently paired with bisphosphonates or hormone replacement therapy (HRT) for comprehensive bone care.

Mechanism: The Absorption Synergy

The reason these two are combined into a single tablet is a matter of biological necessity. Calcium cannot do its job effectively without Vitamin D3.

Vitamin D3 (The Gatekeeper): Once ingested, Vitamin D3 is converted in the body to its active form, Calcitriol. Calcitriol stimulates the synthesis of calcium-binding proteins in the small intestine.

Elemental Calcium (The Building Block): “Elemental” refers to the actual amount of calcium available for the body to absorb (e.g., Calcium Carbonate is 40% elemental calcium). Once absorbed, it is deposited into the bone matrix.

The Result: Together, they maintain Calcium Homeostasis, ensuring that the body doesn’t have to “steal” calcium from the bones to support nerve and muscle function.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai, there are several ways to optimize this product for your digital platforms:

  • Calcium Source Transparency: On your marketplace, specify if you use Calcium Carbonate (highest elemental yield, 40%) or Calcium Citrate (better absorbed on an empty stomach). This technical detail is a major USP for B2B buyers.

  • The “Chewable” Factor: For the geriatric and pediatric markets, offering chewable flavored tablets is a significant selling point. It improves patient compliance for those who have difficulty swallowing large tablets.

  • Stability & Packaging: Vitamin D3 is highly sensitive to light and oxidation. At our facility, we utilize Alu-Alu blister packaging or opaque HDPE bottles with induction sealing to ensure a 36-month shelf life. This is critical for export to tropical Zone IVb regions.

  • Dossier Readiness: As a staple of “Essential Medicine” lists, we provide full CTD/eCTD Dossiers to support your firm in bidding for government health tenders and hospital supply contracts globally.

Calcium Carbonate with Vitamin D3 Tablets

Posted on:

What is calcium carbonate vitamin D3 tablets used for?

In the pharmaceutical industry, the combination of Calcium Carbonate and Vitamin D3 (Cholecalciferol) is a foundational mineral-vitamin supplement. As a pharmacist, I view this formulation as a vital therapeutic tool for bone mineralization and metabolic balance, especially for populations at risk of skeletal degradation.

Primary Clinical Uses

  • Osteoporosis Management: A first-line adjunctive therapy used to increase bone mineral density and reduce the risk of fractures in elderly patients and postmenopausal women.

  • Hypocalcemia: Indicated for the treatment and prevention of low blood calcium levels in patients who do not get enough calcium from their diets.

  • Osteomalacia & Rickets: Used to correct softening of the bones caused by Vitamin D deficiency or impaired calcium absorption.

  • Renal Osteodystrophy: Used as a phosphate binder in patients with chronic renal failure to manage secondary hyperparathyroidism, though this requires strict medical supervision.

Mechanism of Action

This combination is designed for maximum bioavailability:

Calcium Carbonate: Contains a high concentration of elemental calcium (approximately 40%). It serves as a substrate for bone formation and is essential for nerve transmission, muscle contraction, and blood coagulation.

Vitamin D3 (Cholecalciferol): Acts as a hormone precursor that facilitates the active absorption of calcium from the small intestine. Without adequate Vitamin D3, the body cannot absorb calcium efficiently, regardless of how much is ingested.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing standpoint, producing a high-quality Calcium + D3 tablet involves overcoming specific stability and palatability challenges:

  • Elemental Calcium Loading: We often formulate these as 500 mg or 1000 mg tablets. Achieving a high load of Calcium Carbonate while maintaining a manageable tablet size for the patient is a key engineering goal.

  • Vitamin D3 Stability: Vitamin D3 is highly sensitive to light and oxygen. As a WHO-GMP manufacturer, we utilize micro-encapsulated Vitamin D3 to ensure it remains stable and potent throughout the product’s shelf life.

  • Chewable vs. Film-Coated: To improve patient compliance, we offer chewable tablets with advanced taste-masking (like orange or mint) to hide the “chalky” texture of calcium, as well as film-coated versions for those who prefer swallowing.

  • Global Export Logistics: These are high-volume OTC essentials. Our Mumbai-based facility provides Alu-Alu or HDPE bottle packaging to protect the integrity of the Cholecalciferol, especially for export to African and Southeast Asian markets where high humidity is common.

Calcium Carbonate with Vitamin D3 Tablets

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