Healthy Inc > Blog > Allopurinol 100mg tablets
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Why is Allopurinol taken at night?

In the pharmaceutical industry, Allopurinol is a xanthine oxidase inhibitor used as the gold standard for long-term management of hyperuricemia and gout.As a pharmacist and manufacturer, I can clarify that while Allopurinol is not strictly required to be taken at night by its molecular design, there are several pharmacokinetic and clinical reasons why a nighttime (PM) dose is often preferred.

Clinical Reasons for Nighttime Dosing

  • Managing Drowsiness: One of the common, yet often overlooked, side effects of Allopurinol is drowsiness or somnolence. Taking it at night allows the patient to sleep through this effect, improving daily productivity.

  • Gastrointestinal (GI) Tolerance: Allopurinol can cause gastric irritation. Taking it after a large dinner or right before bed (with a full glass of water) helps minimize the risk of nausea and stomach upset.

  • Diurnal Uric Acid Variation: Uric acid levels in the blood tend to fluctuate throughout the 24-hour cycle. Some studies suggest that overnight inhibition of xanthine oxidase aligns better with the body’s natural rhythm of uric acid production and excretion.

Mechanism of Action: Uric Acid Reduction

Allopurinol blocks the production of uric acid at the source.

Enzyme Inhibition: Allopurinol and its active metabolite, Oxypurinol, inhibit the enzyme Xanthine Oxidase.

Stopping the Conversion: This enzyme is responsible for converting hypoxanthine to xanthine, and xanthine into Uric Acid.

Solubility Advantage: By blocking this path, the body keeps purines in the form of hypoxanthine and xanthine, which are more water-soluble and easier for the kidneys to flush out than uric acid.The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your WHO-GMP facility in Mumbai, Allopurinol is a high-volume “Chronic Care” asset:

  • The 100 mg vs. 300 mg Strategy: Most patients start at 100 mg and titrate up to 300 mg. For your digital platform, offering both strengths in scored tablet form is a major USP, as it allows doctors to customize the dose easily.

  • Hydration Guidance: As a pharmacist, your product literature must emphasize that patients should drink 2–3 liters of water daily. This prevents the formation of xanthine stones in the kidneys—a critical technical detail for B2B buyers.

  • Stability & Packaging: Allopurinol is relatively stable but sensitive to high humidity. At our facility, we utilize Alu-Alu blister packaging to ensure a 36-month shelf life, which is essential for export to tropical Zone IVb regions.

  • Dossier Readiness: Since gout is a growing global health concern, we provide full CTD/eCTD Dossiers to support your firm in registering this product for international insurance and government reimbursement programs.

Allopurinol Tablet

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What are allopurinol tablets used for?

In the pharmaceutical industry, Allopurinol tablets (commonly 100 mg and 300 mg) are the gold standard in xanthine oxidase inhibitor therapy. As a pharmacist, I view Allopurinol as a foundational chronic care medication designed not just to treat symptoms, but to chemically recalibrate the body’s uric acid production cycle.

Primary Clinical Uses

  • Gout Management: Used for the long-term prevention of gouty arthritis and the reduction of tophi (uric acid crystal deposits) by lowering serum urate levels.

  • Urate Nephropathy: Prevents the formation of uric acid kidney stones and protects renal function in patients with high urate excretion.

  • Tumor Lysis Syndrome (TLS): Critically used in oncology to prevent acute hyperuricemia in patients undergoing chemotherapy for leukemia or lymphoma.

  • Recurrent Calcium Oxalate Stones: Indicated for patients with recurrent calcium stones who also exhibit high levels of uric acid in their urine.

  • Mechanism of Action

Allopurinol is a structural analogue of the natural purine base, hypoxanthine. It acts by inhibiting the enzyme xanthine oxidase, which is responsible for the conversion of hypoxanthine to xanthine and subsequently xanthine to uric acid. By blocking this enzymatic pathway, Allopurinol reduces the concentration of uric acid in both the blood and urine without interfering with the biosynthesis of vital purines.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing and global trade standpoint, Allopurinol is a high-demand, high-stability molecule that fits perfectly into an export-oriented portfolio:

  • Dosage Versatility: We manufacture both 100 mg (for titration) and 300 mg (for maintenance) strengths to ensure flexible clinical dosing for patients with varying degrees of renal clearance.

  • Pharmacopeial Compliance: Our tablets are manufactured to meet BP/USP/IP standards, ensuring consistent dissolution profiles and high purity levels to minimize the risk of hypersensitivity reactions.

  • Stability for Export: Allopurinol is a robust molecule. As a WHO-GMP certified manufacturer, we ensure our formulations are stable in Zone IVb conditions, making them ideal for long-transit exports to Africa, Southeast Asia, and the CIS region.

  • B2B & Tender Supply: Given its inclusion in the WHO Model List of Essential Medicines, Allopurinol is a primary item for government health tenders and international B2B pharmaceutical marketplaces.

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