Description

Voriconazole Tablets

Healthy Inc is a specialized global supplier and exporter of advanced anti-fungal, oncology support, and critical-care therapeutics. We provide ultra-high-purity, highly bioavailable Voriconazole Film-Coated Tablets (50 mg / 200 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Second-Generation Broad-Spectrum Triazole” is a massive-value, critical-care export to organ transplant centers, hematology/oncology wards, ICU networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the definitive, life-saving intervention for Invasive Aspergillosis and fluconazole-resistant Candidemia.

Product Overview

This formulation contains Voriconazole, an advanced synthetic triazole antifungal engineered to eradicate life-threatening invasive fungal pathogens that are completely resistant to older, first-generation drugs.

The “Invasive Fungal Eradication” Specialist:

• Mechanism (Ergosterol Biosynthesis Blockade): Like all azoles, Voriconazole targets the fungal cell membrane. It binds with incredibly high affinity to the fungal cytochrome P450 enzyme 14-α sterol demethylase. By blocking this enzyme, it completely halts the production of ergosterol. The fungal cell membrane quickly degrades, loses its structural integrity, and the cell dies.
• The Invasive Aspergillosis Gold Standard: Aspergillus is a mold that invades the lungs and brain of immunocompromised patients (like those undergoing chemotherapy or bone marrow transplants), with a notoriously high mortality rate. Voriconazole is the universally mandated, first-line global treatment for this specific, deadly pathogen, vastly outperforming older drugs like Amphotericin B in clinical survival rates.
• Superior Tissue & CNS Penetration: Voriconazole boasts an extraordinary volume of distribution. It rapidly penetrates deep into tissues, including crossing the blood-brain barrier to treat dangerous fungal infections within the central nervous system (CNS), making it invaluable for disseminated (body-wide) fungal outbreaks.

Product Composition & Strength

We supply this product as a Film-Coated Tablet, packed in highly secure, moisture-resistant Alu-Alu blister strips to ensure the stability of the active pharmaceutical ingredient in highly demanding hospital environments.

*Pack Sizes: 1×4, 1×10, or 10×10 Alu-Alu Blisters (Optimized for strict, high-value hospital and ICU dispensing).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Hospital Procurement Boards, and Critical Care Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Non-Linear Pharmacokinetic Engineering: Voriconazole is notorious for its non-linear pharmacokinetics (a small increase in dose can cause a massive, disproportionate spike in blood levels). Our manufacturing utilizes rigorous high-shear blending and HPLC validation to guarantee absolute dose uniformity, preventing fatal toxicities or sub-therapeutic failures in critically ill patients.
• Dissolution Integrity: Highly reliable oral bioavailability (estimated at 96%) allows doctors to rapidly switch patients from IV Voriconazole to our oral tablets, facilitating faster ICU discharge. Our formulation undergoes strict multi-stage dissolution profiling to ensure it matches the absorption kinetics of the originator brand flawlessly.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of severe, progressive, and life-threatening fungal infections:

• Invasive Aspergillosis: The global standard-of-care for pulmonary and disseminated infections caused by Aspergillus species.
• Candidemia (Non-Neutropenic): Treatment of severe Candida infections in the blood, and disseminated Candida infections in skin and deep tissue organs.
• Esophageal Candidiasis: Treatment of severe, refractory oral/esophageal thrush, particularly in HIV/AIDS or oncology patients.
• Rare Fungal Pathogens: Treatment of serious fungal infections caused by Scedosporium apiospermum and Fusarium species (including Fusarium solani) in patients intolerant of, or refractory to, other therapy.

Dosage & Administration

Recommended Dosage (Strictly as per Infectious Disease Specialist/Intensivist):

• Administration (TIMING IS CRITICAL): Voriconazole tablets MUST be taken at least 1 hour before, or 1 hour following, a meal. Taking the drug with high-fat meals drastically reduces its absorption and peak blood concentrations.
• Weight-Based Dosing: Therapy often requires a “loading dose” (e.g., 400 mg every 12 hours for the first 24 hours) followed by a maintenance dose (e.g., 200 mg every 12 hours) based strictly on the patient’s body weight.

Safety Warnings (CRITICAL):

• Visual Disturbances (“Voriconazole Vision”): Up to 30% of patients experience transient visual disturbances, including altered color perception, blurred vision, and extreme photophobia (sensitivity to light). These typically occur within 30 minutes of taking the pill and resolve over time. Patients must not drive or operate machinery at night.
• BLACK BOX EQUIVALENT (Severe CYP450 Interactions): Voriconazole is a profound inhibitor of hepatic cytochrome P450 enzymes (CYP2C19, CYP2C9, and CYP3A4). It is strictly contraindicated with numerous drugs (e.g., Sirolimus, Rifampin, Carbamazepine, long-acting barbiturates, and certain statins) due to the risk of fatal toxicities or total loss of antifungal efficacy.
• Hepatotoxicity & Phototoxicity: Severe, potentially fatal liver injury has been reported; liver function tests (LFTs) must be monitored closely. Additionally, long-term use causes severe skin phototoxicity. Patients must strictly avoid direct sunlight, as prolonged exposure is linked to the development of squamous cell skin cancer.
• Teratogenicity: Can cause fetal harm. Effective contraception is mandatory during therapy.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Antifungal and Critical Care Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for oncology wards in LATAM or a B2B Pharma Marketplace partner for the Middle East, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Specialty Medicine Wholesaler receives WHO-GMP certified products at competitive rates.