Description

Voglibose & Metformin (SR) Tablets

Healthy Inc is a specialized global supplier and exporter of advanced endocrinology, metabolic, and glycemic control therapeutics. We provide high-purity, multi-kinetic Voglibose (0.2 mg / 0.3 mg) & Metformin Hydrochloride (500 mg Sustained-Release) Bilayer Tablets, manufactured in WHO–GMP certified, high-capacity oral solid dosage facilities. This “Dual-Action Glycemic Control Synergy” is a massive-volume, essential export to diabetic care centers, primary care networks, retail pharmacy distributors, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the definitive intervention for progressive Type 2 Diabetes Mellitus that is uncontrolled by monotherapy.

Product Overview

This advanced Fixed-Dose Combination (FDC) brilliantly synchronizes two entirely different classes of oral anti-diabetic agents to achieve comprehensive, 24-hour blood glucose mastery.

The “Fasting & Post-Prandial Mastery” Specialist:

• Mechanism 1 (Voglibose – The Post-Meal Blocker): Voglibose is a highly potent alpha-glucosidase inhibitor. It competitively and reversibly blocks the enzymes in the intestinal brush border that are responsible for breaking down complex carbohydrates into simple sugars. By delaying carbohydrate digestion, it violently flattens the dangerous, immediate spike in blood glucose that occurs right after eating (Post-Prandial Hyperglycemia).
• Mechanism 2 (Metformin – The Hepatic Suppressor): Metformin (a Biguanide) is the undisputed global bedrock of diabetes care. It works systemically to reduce fasting blood glucose by violently suppressing the liver’s natural production of glucose (gluconeogenesis) and significantly increasing the insulin sensitivity of peripheral muscle tissues, forcing the body to use the insulin it already has.
• The Bilayer Sustained-Release Advantage: Standard Metformin causes severe gastrointestinal upset and wears off quickly. Our advanced formulation utilizes a polymer matrix to slowly release the Metformin over 24 hours, guaranteeing steady, round-the-clock fasting glucose control, while the Voglibose layer dissolves instantly to combat the immediate mealtime sugar spike.

Product Composition & Strength

We supply this product as a highly advanced Bilayer Film-Coated Tablet, packed in highly secure, moisture-resistant Alu-Alu blister strips. Alu-Alu packaging is completely non-negotiable, as Voglibose is highly sensitive to moisture degradation.

*Pack Sizes: 10×10 or 10×15 Alu-Alu Blisters (Optimized for 30-day chronic diabetic dispensing regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Endocrinology Distributors, and NGOs.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Bilayer Tablet Engineering: Manufacturing a dual-kinetic tablet requires advanced, high-tonnage bilayer rotary presses. The Metformin granules are coated in a specialized slow-release polymer (HPMC) and compressed as the foundation layer. The micro-dosed Voglibose is then geometrically blended and compressed directly on top as an immediate-release layer. This physically isolates the active ingredients and guarantees two entirely separate dissolution profiles in the human gut.
• Micro-Dose Uniformity Verification: Voglibose is dosed in fractions of a milligram (0.2mg or 0.3mg). Our facilities utilize advanced high-shear homogenizers and rigorous HPLC assay testing to guarantee absolute dose uniformity, preventing fatal hypoglycemic “hot spots” within the batch.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of complex metabolic disorders:

• Type 2 Diabetes Mellitus (T2DM): Second-line therapy for patients with Type 2 Diabetes whose blood sugar levels are not adequately controlled by diet, exercise, and Metformin monotherapy alone, specifically targeting those with severely elevated post-prandial (after-meal) glucose spikes.

Dosage & Administration

Recommended Dosage (Strictly as per Endocrinologist/Physician):

• Administration (THE “FIRST BITE” RULE IS CRITICAL): To be effective, the Voglibose layer must be present in the intestine *before* the food arrives. These tablets MUST be taken immediately before or with the very first bite of a main meal. If taken after the meal, the Voglibose component is entirely useless.
• Swallowing Protocol: Because the Metformin is in a Sustained-Release matrix, the tablet MUST be swallowed whole with a glass of water. It must never be crushed, chewed, or split, as this will destroy the slow-release mechanism and cause massive gastrointestinal distress.

Safety Warnings (CRITICAL):

• BLACK BOX WARNING (Lactic Acidosis): Metformin carries a rare but extremely fatal risk of lactic acidosis (a buildup of lactic acid in the blood). This risk is massively elevated in patients with severe renal impairment, hepatic disease, or congestive heart failure. The drug must be temporarily discontinued prior to any intravascular radiocontrast imaging studies.
• Gastrointestinal Distress (Flatulence/Diarrhea): Because Voglibose stops carbohydrates from being absorbed in the small intestine, those carbs ferment in the large intestine. This frequently causes severe flatulence, bloating, and diarrhea. Patients must be counseled that this is expected and usually subsides over time.
• Hypoglycemia Protocol (CRITICAL RESCUE WARNING): While this specific combination rarely causes severe hypoglycemia on its own, if a patient’s blood sugar does drop too low (especially if taking insulin or sulfonylureas concurrently), they MUST be treated with pure Dextrose (Glucose) powder or tablets. They cannot be treated with table sugar (sucrose) or complex carbs, because the Voglibose will block the body from absorbing it in time to save their life.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Endocrinology Formulations, allowing brands to launch high-quality generic medicines under their essential label. Whether you are looking for a reliable Hospital Tender Supplier for government diabetic programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.