Description

Vancomycin Hydrochloride for Injection

Healthy Inc is a specialized global supplier and exporter of critical care antimicrobials and life-saving antibiotics. We provide high-purity Vancomycin for Injection (500 mg / 1000 mg), manufactured in WHO–GMP certified sterile lyophilization facilities. This “First-Line Glycopeptide” is a mandatory export to intensive care units (ICU), infectious disease centers, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the definitive, global gold-standard intervention for severe, multi-drug-resistant Gram-positive infections, specifically Methicillin-Resistant Staphylococcus aureus (MRSA).

Product Overview

This formulation contains Vancomycin Hydrochloride, a massive, tricyclic glycopeptide antibiotic originally derived from the soil bacterium Amycolatopsis orientalis.

The “Gram-Positive / MRSA” Specialist:

• Mechanism (Cell Wall Blockade): Vancomycin works by physically binding to the D-alanyl-D-alanine precursor units of the bacterial cell wall. Because of its large molecular size, this binding acts as a massive steric shield, blocking the transglycosylase enzymes from cross-linking the peptidoglycan matrix. The bacterial cell wall rapidly weakens, leading to osmotic lysis and cell death.
• The MRSA Backbone: It is highly bactericidal against Gram-positive bacteria, including severe penicillin- and cephalosporin-resistant strains (MRSA, MRSE) and Enterococci. (Note: It is too large to pass through the porin channels of Gram-negative bacteria, rendering it completely inactive against them).
• Time-Dependent Killing: Vancomycin efficacy is driven by the Area Under the Curve (AUC) relative to the Minimum Inhibitory Concentration (MIC). Maintaining adequate serum trough levels is critical to penetrating deep tissue infections and preventing resistance.

Product Composition & Strength

We supply this product as a Sterile Lyophilized Powder (White to Off-White Plug/Cake) in glass vials, requiring two-step reconstitution and dilution prior to intravenous administration.

*Pack Sizes: Single Vial or Tray of 10 Vials.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Chromatographic Purity: Early preparations of Vancomycin in the 1950s contained impurities dubbed “Mississippi Mud,” which caused severe renal toxicity. Our modern manufacturing utilizes advanced high-performance liquid chromatography (HPLC) purification to ensure an exceptionally pure API, drastically reducing the baseline risk of nephrotoxicity.
• Aseptic Lyophilization: Aseptic filtration and filling under Grade A laminar airflow guarantee a 100% pyrogen-free product, mandatory for central-line infusions in critically ill, septic patients.

Therapeutic Indications (Human Use)

Indicated for the treatment of severe or life-threatening staphylococcal and streptococcal infections:

• MRSA Infections: Septicemia, bone and joint infections (osteomyelitis), lower respiratory tract infections (pneumonia), and complicated skin and skin structure infections (cSSSI).
• Infective Endocarditis: Caused by Staphylococcus aureus (including methicillin-resistant strains), Streptococcus viridans, or Enterococcus species (often combined with an aminoglycoside like Tobramycin/Gentamicin).
• Penicillin Allergy: Primary alternative for severe Gram-positive infections in patients with life-threatening allergies to penicillins and cephalosporins.

Dosage & Administration

Recommended Dosage (Strictly as per Infectious Disease Specialist):

• Route: Intravenous (IV) Infusion ONLY.
• CRITICAL WARNING (Route): DO NOT ADMINISTER AS AN IV BOLUS (PUSH) OR INTRAMUSCULARLY (IM). IM injection causes severe pain and deep tissue necrosis. Rapid IV push causes fatal cardiac arrest.
• Standard Adult Dose: Typically 15 to 20 mg/kg every 8 to 12 hours based on total body weight and renal function.
• Infusion Rate Constraint: The concentration of the diluted solution must not exceed 5 mg/ml, and it MUST be infused slowly over a minimum of 60 minutes (or longer for doses exceeding 1 gram).

Safety Warnings (CRITICAL):

• “Red Man Syndrome” (Infusion Reaction): Rapid IV administration triggers a massive, non-immunologic release of histamine, causing severe flushing, intense pruritus (itching), an erythematous rash on the face/neck/upper torso, and dangerous hypotension. Slowing the infusion rate over 1 to 2 hours prevents this.
• Nephrotoxicity & Ototoxicity: Can cause acute kidney injury and permanent hearing loss (especially high-frequency deafness). Risk exponentially increases if co-administered with other nephrotoxic drugs (e.g., Aminoglycosides, Loop Diuretics).
• Therapeutic Drug Monitoring (TDM): Serum trough levels must be routinely drawn immediately prior to the 4th dose to ensure therapeutic efficacy (typically targeting 15-20 mcg/ml for severe infections) while avoiding toxic accumulation.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Critical Care Antibiotics, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.