Description

Thiocolchicoside Tablets / Capsules

Healthy Inc is a specialized global supplier and exporter of advanced orthopedic, rheumatological, and acute pain management therapeutics. We provide ultra-high-purity, kinetically precise Thiocolchicoside Tablets & Capsules (4 mg / 8 mg), manufactured in WHO–GMP certified, high-capacity oral solid dosage facilities. This “Plant-Derived Centrally Acting Muscle Relaxant” is a massive-volume, premium export to orthopedic trauma centers, physiotherapy clinics, sports medicine networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the globally trusted, short-term intervention for acute, painfully restricted spinal muscle spasms.

Product Overview

This formulation contains Thiocolchicoside, a semi-synthetic sulfur derivative of colchicoside (a naturally occurring glucoside extracted from the seeds of the Gloriosa superba plant). It offers a unique pharmacological profile distinct from standard centrally acting relaxants.

The “Acute Spinal Spasm & Trauma” Specialist:

• Mechanism (GABA & Glycine Modulation): Unlike benzodiazepines that universally depress the brain, Thiocolchicoside exhibits selective affinity for GABA-A and strychnine-sensitive glycine receptors in the central nervous system. By acting on complex supraspinal and spinal reflex pathways, it aggressively interrupts the neurological loop that causes severe muscle contractures and stiffness, particularly those originating from spinal column pathologies.
• The Analgesic Synergy: Beyond purely relaxing the muscle fiber, Thiocolchicoside possesses inherent anti-inflammatory and analgesic (pain-relieving) properties. This dual-action approach drastically reduces the patient’s reliance on high doses of concurrent NSAIDs or opioids during an acute orthopedic crisis.
• Non-Sedating Profile: Similar to Tolperisone, Thiocolchicoside provides profound muscle relaxation without causing the severe, paralyzing drowsiness or respiratory depression associated with legacy drugs like Carisoprodol or Diazepam, allowing for functional daytime recovery.

Product Composition & Strength

We supply this product as a Precision-Blended Film-Coated Tablet or Hard Gelatin Capsule, packed in highly secure, moisture-resistant Alu-Alu blister strips to ensure the absolute stability of the semi-synthetic active ingredient.

*Pack Sizes: 10×10 Alu-Alu Blisters (Optimized specifically for strict 7-day acute dispensing limits).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Orthopedic Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Low-Dose Geometric Blending: Because the active ingredient is potent at just 4 mg, uneven powder distribution can lead to sub-therapeutic failure or increased risk of localized toxicity. Our facilities utilize advanced high-shear homogenizers and rigorous geometric dilution protocols, verified by HPLC assay, to guarantee absolute dose uniformity across the entire batch.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of acute, pathological muscle tone:

• Acute Orthopedic Spasms: Adjuvant treatment for painful, acute muscle contractures in acute spinal pathology (e.g., severe lumbago, sciatica, torticollis, and post-traumatic muscle spasms).
• Note: It is strictly NOT indicated for chronic conditions or neurological spasticity (like Multiple Sclerosis or Cerebral Palsy).

Dosage & Administration

Recommended Dosage (Strictly as per EMA and Global Orthopedic Guidelines):

• Maximum Adult Dosing: The recommended maximum dose is 8 mg every 12 hours (i.e., a maximum total of 16 mg per day).
• THE 7-DAY LIMITATION (CRITICAL COMPLIANCE): Due to potential genotoxic risks associated with its metabolite, oral treatment must be strictly limited to a maximum of 7 consecutive days. It must never be prescribed for long-term or chronic use.
• Administration: Must be taken orally with a glass of water, ideally after meals to minimize any mild gastrointestinal discomfort.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX EQUIVALENT (Aneuploidy & Genotoxicity): Extensive clinical reviews (including by the European Medicines Agency) have established that a metabolite of Thiocolchicoside (M2) can cause aneuploidy (an abnormal number of chromosomes in dividing cells) at high doses or prolonged exposure. Aneuploidy is a risk factor for teratogenicity, embryotoxicity/abortion, impaired male fertility, and theoretical cancer development. Therefore, the strict 7-day dosing limit is absolute.
• Pregnancy & Contraception: It is strictly contraindicated in pregnancy and lactation, and contraindicated in women of childbearing potential who are not using highly effective contraception.
• Seizure Risk: Thiocolchicoside may lower the seizure threshold. It is contraindicated in patients with epilepsy or a history of seizure disorders.
• Gastrointestinal Intolerance: May occasionally cause diarrhea, nausea, or gastralgia. Severe diarrhea warrants immediate discontinuation of the drug.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Orthopedic and Neuromuscular Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for acute trauma centers in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.