Description
Hydrochlorothiazide Tablets
Healthy Inc is a specialized global supplier and exporter of essential diuretic agents. We provide high-purity Hydrochlorothiazide (HCTZ) Tablets, sourced from WHO–GMP certified solid dosage facilities. This “First-Line” diuretic is a top export to cardiology clinics, geriatric care homes, and government hypertension programs in Africa, LATAM, and Southeast Asia, serving as the foundational therapy for blood pressure control and edema management.
Product Overview
This formulation contains Hydrochlorothiazide, a thiazide diuretic.
The “Volume Control” Specialist:
- Mechanism: It acts on the **distal convoluted tubule** of the kidney nephron. It inhibits the Na+/Cl- symporter, preventing the reabsorption of sodium and chloride. By keeping salt in the urine, it forces water to follow (osmosis), increasing urine output.
- Antihypertensive Action:
- Initial: Reduces blood volume and cardiac output.
- Long-term: Reduces peripheral vascular resistance (vasodilation), making it effective even after blood volume normalizes.
- Synergy Booster: HCTZ is rarely used alone for severe hypertension. It is the perfect **”Potentiator”**—when added to ACE Inhibitors (like Enalapril) or ARBs (like Losartan), it doubles their effectiveness by counteracting fluid retention.
- Calcium Sparing: Unlike Loop diuretics (Furosemide) that waste calcium, HCTZ helps the body retain calcium, offering a secondary benefit for osteoporotic patients.
Product Composition & Strength
We supply this product as Uncoated Tablets (scored for titration). Accurate low-dose titration is critical for modern therapy.
| Active Ingredient | Strength (Standard) | Role |
|---|---|---|
| Hydrochlorothiazide USP/BP | 12.5 mg | Initial Dose / Combination Use |
| Hydrochlorothiazide USP/BP | 25 mg | Standard Therapeutic Dose |
| Hydrochlorothiazide USP/BP | 50 mg | Edema / High Potency |
| Excipients | Q.S. | Lactose (Filler) / Starch |
*Pack Sizes: Blister packs of 10s, 14s, 28s (Calendar Pack), or Bulk HDPE Jars of 1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Oral) |
| Packaging | PVC-Alu Blister or HDPE Jar |
| Storage | Store below 25°C. Protect from moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Content Uniformity: The 12.5 mg dose is very small relative to the tablet size. We use high-shear granulation technology to ensure the API is perfectly distributed, preventing “hot spots” (overdose) or “dead spots” (underdose) in the batch.
- Dissolution: Optimized for rapid release (>80% in 30 mins) to ensure predictable onset of diuresis (usually within 2 hours).
Therapeutic Indications (Human Use)
Indicated for the management of fluid overload and pressure:
- Essential Hypertension: As sole therapy or in combination with other antihypertensive agents.
- Edema: Associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
- Renal Dysfunction: Edema due to various forms of renal dysfunction (e.g., nephrotic syndrome).
- Calcium Nephrolithiasis: Prevention of calcium kidney stones (off-label use due to calcium retention).
Dosage & Administration
Recommended Dosage (Strictly as per Physician):
- Route: Oral.
- Hypertension: Initially 12.5 mg to 25 mg once daily. Doses above 50 mg/day usually do not lower BP further but increase side effects.
- Edema: 25 mg to 100 mg daily, given as a single or divided dose. Many patients benefit from intermittent therapy (e.g., every other day).
- Timing: Best taken in the morning. Taking it at night causes “Nocturia” (waking up to urinate), which disrupts sleep.
Safety Warnings:
- Electrolyte Imbalance:
- Hypokalemia: Lowers potassium. Patients may need to eat bananas or take potassium supplements.
- Hyponatremia: Lowers sodium. Monitor in elderly.
- Sulfa Allergy: HCTZ is a sulfonamide. Contraindicated in patients with severe allergy to sulfa drugs.
- Metabolic Effects: Can raise blood sugar (Hyperglycemia) and Uric Acid levels (Hyperuricemia), potentially triggering Gout attacks.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
