Description

Digoxin Injection

Healthy Inc is a specialized global supplier and exporter of narrow-therapeutic-index cardiac glycosides. We provide high-purity Digoxin Injection (500 mcg / 2 ml), sourced from WHO–GMP certified sterile injectable facilities. This “Heart Force Multiplier” is a top export to cardiology intensive care units (ICCU), emergency departments, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the classic, rapid-acting agent for controlling ventricular rate in Atrial Fibrillation and improving contractility in acute Heart Failure.

Product Overview

This formulation contains Digoxin, a purified cardiac glycoside extracted from the foxglove plant (*Digitalis lanata*).

The “Inotrope & Chronotrope” Specialist:

• Mechanism (The “Pump Blocker”): Digoxin inhibits the Na+/K+ ATPase pump in cardiac cell membranes. This leads to an increase in intracellular Sodium, which drives the Sodium-Calcium exchanger to bring more Calcium into the cell.
  • Positive Inotropy: Increased Calcium causes the heart muscle to contract with greater force (useful in Heart Failure).
  • Negative Chronotropy: It stimulates the Vagus nerve, slowing down electrical conduction through the AV node (critical for slowing rapid heart rate in Atrial Fibrillation).
• Rapid Control: IV Digoxin acts within 5-30 minutes, making it essential for acute rate control in patients who cannot tolerate beta-blockers due to hypotension.

Product Composition & Strength

We supply this product as a Sterile Solution in Glass Ampoules.

*Pack Sizes: Tray of 5 Ampoules, 10 Ampoules, or 50 Ampoules.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Content Uniformity (Critical): Digoxin has a very Narrow Therapeutic Index (toxic dose is very close to therapeutic dose). Our manufacturing process employs rigorous “Content Uniformity” testing to ensure every single ampoule contains exactly 500mcg. A variation of even 10% can be dangerous.
• Glass Adsorption Prevention: Digoxin can adsorb (stick) to plastics. We use treated Type I Glass ampoules to ensure the drug remains in the solution and is not lost to the container walls during storage.

Therapeutic Indications (Human Use)

Indicated for cardiac disorders requiring rate control or inotropic support:

• Atrial Fibrillation (AFib): For ventricular rate control (slowing the heart beat), especially in sedentary patients or those with Heart Failure.
• Heart Failure: To increase myocardial contractility and reduce hospitalization in patients with reduced ejection fraction (HFrEF).
• Paroxysmal Supraventricular Tachycardia (PSVT): As a second-line agent.

Dosage & Administration

Recommended Dosage (Strictly as per Cardiologist – High Toxicity Risk):

• Route: Slow Intravenous (IV) Injection ONLY. (IM is painful and absorption is erratic – Avoid).
• Digitalizing (Loading) Dose: 0.25 to 0.5 mg (250-500 mcg) IV over 5-10 minutes. May repeat 0.25 mg every 4-6 hours to a total of 1.0 mg.
• Maintenance Dose: 0.125 mg to 0.25 mg daily (Oral or IV).
• Renal Impairment: Drastic dose reduction required. Digoxin is excreted by kidneys. Reduce dose by 50-75% in renal failure to prevent fatal toxicity.

Safety Warnings (CRITICAL):

• Digoxin Toxicity: Symptoms include nausea, vomiting, visual disturbances (yellow/green halos around lights), and life-threatening arrhythmias (heart block, VT).
• Hypokalemia (Low Potassium): Low potassium increases Digoxin toxicity. Patients on Diuretics (Furosemide) are at high risk. Serum Potassium must be normalized before administration.
• Monitor Heart Rate: Withhold dose if Pulse < 60 bpm.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.