Description

Cytarabine Injection

Healthy Inc is a specialized global supplier and exporter of essential hematology-oncology agents. We provide high-purity Cytarabine Injection (100 mg / 500 mg / 1 g), sourced from WHO–GMP certified sterile cytotoxic facilities. Known as “Ara-C,” this antimetabolite is a top export to hematology wards, bone marrow transplant units, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the absolute cornerstone of induction therapy for Acute Myeloid Leukemia (AML).

Product Overview

This formulation contains Cytarabine (Cytosine Arabinoside), a pyrimidine analogue that specifically targets rapidly dividing cells in the S-phase of the cell cycle.

The “Leukemia” Specialist:

• Mechanism (The “False Nucleotide”): Cytarabine mimics the structure of the normal nucleoside cytidine. Once inside the cell, it is converted to Ara-CTP and incorporated into DNA. It acts as a chain terminator and inhibits DNA Polymerase, effectively stopping DNA replication and killing the cancer cell.
• The “7+3” Regimen: It is the “7” in the global standard “7+3” induction regimen for AML (7 days of continuous Cytarabine infusion + 3 days of an Anthracycline), used to clear leukemic blasts from the marrow.
• Meningeal Leukemia: Because it crosses the blood-brain barrier, it is crucial for treating or preventing leukemia that has spread to the central nervous system (CNS).

Product Composition & Strength

We supply this product as a Sterile Solution (Liquid) or Lyophilized Powder.

*Pack Sizes: Tray of 1 Vial, 5 Vials, or Box of 1/10 Vials.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Intrathecal Safety: We offer specific batches that are Preservative-Free (No Benzyl Alcohol). This is critical because Benzyl Alcohol is neurotoxic and must never be injected into the spine (intrathecal). Our labeling clearly distinguishes between “IV Only” and “IT Compatible” vials.
• Crystal Prevention: High-concentration Cytarabine can crystallize at low temperatures. Our manufacturing process ensures stable solubility at room temperature, preventing the formation of micro-crystals that could cause embolisms.

Therapeutic Indications (Human Use)

Indicated for the induction and maintenance of remission in:

• Acute Myeloid Leukemia (AML): Adults and pediatric patients.
• Acute Lymphoblastic Leukemia (ALL): Second-line or maintenance therapy.
• Meningeal Leukemia: Prophylaxis and treatment (Intrathecal route).
• Chronic Myelogenous Leukemia (CML): Blast phase.
• Non-Hodgkin’s Lymphoma: High-dose regimens for refractory cases.

Dosage & Administration

Recommended Dosage (Strictly as per Hematologist):

• Route: IV Infusion, SC, or Intrathecal (IT).
• AML Induction (Standard): 100-200 mg/m²/day as Continuous IV Infusion for 7 days (“7+3” regimen).
• High-Dose Ara-C (HiDAC): 2 g to 3 g/m² every 12 hours for refractory AML (Requires strict neuro-monitoring).
• Intrathecal (Meningeal): 5 mg to 75 mg/m² (range varies). MUST USE PRESERVATIVE-FREE VIAL.
• Subcutaneous (SC): Low dose maintenance (10-20 mg/m²).

Safety Warnings (CRITICAL):

• Cytarabine Syndrome: Occurs 6-12 hours after administration. Symptoms include fever, myalgia, bone pain, maculopapular rash, and conjunctivitis. Treated with Corticosteroids.
• Cerebellar Toxicity: High doses (HiDAC) can cause ataxia, dysarthria, and nystagmus. Immediate discontinuation required to prevent permanent brain damage. Perform neurological checks before every dose.
• Bone Marrow Suppression: Profound leukopenia, thrombocytopenia, and anemia are expected and inevitable. Support with blood products and G-CSF is standard.
• Chemical Conjunctivitis: High doses cause painful eye inflammation. Prophylactic steroid eye drops (Dexamethasone) are mandatory.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.