Description
Cefpodoxime Proxetil Dispersible Tablets (50 mg / 100 mg)
Healthy Inc is a specialized global supplier and exporter of advanced anti-infectives, pediatric medicine, and targeted 3rd-generation cephalosporin therapeutics. We provide ultra-high-purity, kinetically optimized Cefpodoxime Proxetil Dispersible Tablets (50 mg / 100 mg), manufactured in WHO–GMP certified, dedicated Beta-Lactam high-containment facilities. This “3rd-Generation Cephalosporin & Extended-Spectrum Antibiotic” is a massive-volume, premium export to pediatric hospitals, ENT clinics, and government health ministries, serving as the globally mandated intervention for community-acquired pneumonia, acute otitis media, and switch-therapy from IV Ceftriaxone.
Product Overview
This formulation operates as a structural saboteur of highly resilient bacteria. As a 3rd-generation agent, it possesses enhanced stability against $\beta$-lactamases and expanded coverage against Gram-negative pathogens that have developed resistance to older penicillins and 1st-gen cephalosporins.
Mechanism 1 (The PBP-3 Target): Cefpodoxime binds with extreme affinity to Penicillin-Binding Proteins (PBPs), particularly PBP-3. This halts the cross-linking of the peptidoglycan layer during the final stages of bacterial cell wall assembly, causing the cell to lose its structural integrity.
Mechanism 2 (The 3rd-Gen Spectrum): Unlike 1st or 2nd-gen agents, Cefpodoxime is devastatingly effective against Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae, making it a “Gold Standard” for complex respiratory and urinary infections.
Mechanism 3 (The Proxetil Prodrug Kinetic): Cefpodoxime itself is poorly absorbed. The Proxetil ester makes the molecule lipophilic, ensuring high intestinal absorption. Once in the blood, esterases “unlock” the active Cefpodoxime, delivering a sustained, high-concentration bactericidal payload.
Product Composition & Strength
We supply this product as a Precision-Blended, Rapidly Disintegrating (DT) Matrix, packed in high-barrier Alu-Alu blister strips.
| Active Ingredient | Strength | Primary Clinical Function |
| Cefpodoxime Proxetil USP/Ph.Eur. | 50 mg / 100 mg | The Pediatric & Titration Anchor: Dispersible format for easy administration in children and elderly patients with swallowing difficulties. |
| Excipients | Sweetening & Flavoring Agents | Bitter-Shield Technology: Engineered with molecular masking agents (e.g., Cyclodextrins) to neutralize the intense bitterness of the API, ensuring 100% pediatric compliance. |
| Disintegrants | Croscarmellose Sodium / SSG | Instant-Dispersible Matrix: Engineered to shatter and form a uniform suspension in < 60 seconds when placed in 5-10 mL of water. |
Technical & Logistics Specifications
HS Code: 3004.20.00 (Medicaments containing antibiotics)
CAS Number: 87239-81-4 (Cefpodoxime Proxetil)
Dosage Form: Dispersible Tablet (DT) / Orally Disintegrating
Packaging: Alu-Alu Blisters (STRICTLY MANDATORY). Cefpodoxime Proxetil is highly sensitive to moisture and light. Alu-Alu packaging ensures 24-month stability in Zone IVb tropical climates.
Manufacturing Authority & Compliance
Dedicated Beta-Lactam Containment: To prevent life-threatening cross-contamination, our production occurs in Strictly Isolated Beta-Lactam Blocks with dedicated HVAC and HEPA filtration systems.
High-Shear Dispersion Engineering: We utilize advanced high-shear granulators to ensure the Micronized API is perfectly distributed within the dispersible matrix, preventing “grittiness” and ensuring rapid, uniform suspension.
Dosage & Administration
Standard Dosing: Usually 100 mg to 200 mg every 12 hours for adults, or weight-based dosing for pediatrics (e.g., 10 mg/kg/day).
The “Water Mandate”: The tablet should be dispersed in a small amount (5-10 mL) of boiled and cooled water. The resulting suspension must be consumed immediately.
Absorption Note: Unlike other cephalosporins, the bioavailability of Cefpodoxime Proxetil is significantly increased when taken with food.
Safety Warning: Strictly contraindicated in patients with cephalosporin hypersensitivity. 10% cross-reactivity risk in penicillin-allergic patients. Avoid concurrent use with H2-antagonists or antacids, as high gastric pH drastically reduces absorption.
Global Export & Contract Manufacturing
Healthy Inc is a premier Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for specialized Pediatric Antibiotics and DT Formulations. Whether you are a Government Tender Supplier for child health in Africa or a B2B Pharma Marketplace partner in Southeast Asia, we ensure secure, WHO-GMP compliant delivery.
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