AMILORIDE + HYDROCHLORTHIAZIDE TABLET

Description

Amiloride & Hydrochlorothiazide Tablets (5 mg / 50 mg)

Healthy Inc is a specialized global supplier and exporter of advanced cardiology, nephrology, and targeted internal medicine therapeutics. We provide ultra-high-purity, kinetically balanced Amiloride & Hydrochlorothiazide FDC Tablets, manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Potassium-Sparing & Thiazide Diuretic FDC” is a massive-volume strategic export to hypertension clinics, cardiac hospitals, and government health ministries, serving as the globally mandated intervention for Essential Hypertension and Congestive Heart Failure where potassium maintenance is critical.

Product Overview

This formulation operates as a “Synchronized Fluid Regulator.” It is specifically engineered to remove excess fluid from the body while “locking” essential minerals in the bloodstream, preventing the electrolyte imbalances common with older diuretics.

• Mechanism 1 (The Volume Reducer – Hydrochlorothiazide): HCTZ acts on the Distal Convoluted Tubule of the kidney. It inhibits sodium and chloride reabsorption, causing the body to excrete more salt and water, which naturally lowers blood pressure and reduces swelling (Edema).

• Mechanism 2 (The Potassium Guard – Amiloride): Amiloride is a Potassium-Sparing Diuretic. It blocks the Epithelial Sodium Channels (ENaC) in the collecting duct. This prevents the “leakage” of potassium into the urine, which is the primary side effect of HCTZ monotherapy.

• Mechanism 3 (The Hemodynamic Balance): By combining these two mechanisms, the drug provides a more powerful diuretic effect than either drug alone, while maintaining a stable level of potassium in the blood, which is vital for a healthy heart rhythm.

Product Composition & Strength

We supply this product in the globally standardized strength ratio, packed in high-barrier Alu-PVC or Alu-Alu blister strips.

Technical & Logistics Specifications

• HS Code: 3004.90.69 (Medicaments containing other active substances – Cardiovascular/Diuretics)

• CAS Numbers: 2016-88-8 (Amiloride HCl) / 58-93-5 (Hydrochlorothiazide)

• Dosage Form: Uncoated or Film-Coated Tablet (Scored for half-dosing)

• Packaging: Alu-Alu or Alu-PVC Blisters. Our packaging ensures 24-month stability even in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Content Uniformity Excellence: Our facility utilizes Advanced Dry Granulation to ensure the 5 mg Amiloride is distributed with 100% uniformity across every tablet, ensuring every dose provides consistent electrolyte protection.

• API Purity Monitoring: We utilize high-purity minerals that meet the latest global safety standards, ensuring no heavy metal contamination, which is critical for long-term chronic therapy.

Primary Indications

• Cardiology: Treatment of Essential Hypertension (High Blood Pressure).

• Critical Care: Management of Edema (fluid retention) associated with Congestive Heart Failure.

• Nephrology: Treatment of edema caused by Hepatic Cirrhosis or Nephrotic Syndrome.

Dosage & Administration

• Standard Adult Dosing: Initially 1 tablet once daily. If necessary, the dose may be increased to 2 tablets daily, but should not exceed this.

• Administration: Best taken in the morning after breakfast to avoid nighttime urination (Nocturia).

Safety Warning: Hyperkalemia Risk. Avoid in patients with high potassium levels or severe kidney failure. Do not take potassium supplements or salt substitutes containing potassium unless directed by a doctor. Monitor serum electrolytes periodically.

Global Export & Contract Manufacturing

Healthy Inc is a premier Cardiovascular Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for essential Diuretic FDCs. Whether you are a National Health Tender Buyer in Africa or a B2B Pharma Marketplace partner in the CIS, we ensure secure, WHO-GMP compliant delivery.