Description
Adefovir Dipivoxil Tablets
Adefovir Dipivoxil Tablets (10 mg)
Healthy Life Pharma Private Limited, alongside our specialized global marketing and export division Healthy Inc, is a premier manufacturer, supplier, and exporter of advanced antiviral, infectious disease, and hepatology therapeutics. We manufacture ultra-high-purity, kinetically stable Adefovir Dipivoxil Tablets in our WHO–GMP certified, high-containment solid dosage manufacturing facilities. This foundational “Nucleotide Analogue Reverse Transcriptase Inhibitor” serves as an essential strategic export to hepatology centers, state hospital networks, international B2B wholesale marketplaces, and government tender procurement pipelines across Africa, the CIS region, and South-East Asia.
Product Overview
This formulation operates as a “Viral DNA Chain Terminator.” It ensures patient safety by chemically blocking the replication mechanism of the Hepatitis B Virus (HBV), halting the progression of liver inflammation and fibrosis.
Mechanism 1 (Active Metabolite Conversion): Adefovir Dipivoxil is an orally bioavailable prodrug. Upon absorption, it is physically cleaved by cellular esterases into its active chemical form, Adefovir Diphosphate.
Mechanism 2 (Competitive Inhibition): The active drug chemically competes with the natural substrate, deoxyadenosine triphosphate, to physically bind to the HBV DNA Polymerase (Reverse Transcriptase) enzyme.
Mechanism 3 (DNA Chain Termination): Once incorporated into the growing viral DNA strand, it chemically prevents the attachment of further nucleotides. Because it lacks a 3′-hydroxyl group, it physically forces Instant Chain Termination, completely stopping viral replication.
Product Composition & Strengths
We supply this therapeutic in the globally accepted standard therapeutic strength optimized for adult daily maintenance therapy.
| Active Ingredient | Standard Strength | Primary Clinical Target |
| Adefovir Dipivoxil IP / BP / USP | 10 mg | The Polymerase Blocker: Daily oral dose to suppress chronic Hepatitis B viral loads. |
| Excipients | Pharma Grade | The Matrix: High-stability lactose/microcrystalline cellulose binders. |
Technical & Logistics Specifications
HS Code: 3004.90.99 (Medicaments acting on infectious diseases / Antivirals)
CAS Number: 142340-99-6 (Adefovir Dipivoxil)
Dosage Form: Oral Solid Tablet
Packaging: 10 or 30 Tablets per Blister in high-barrier Alu-Alu (Cold-Form Foil) packs or induction-sealed HDPE bottles containing integrated desiccant canisters. Our tropicalized packaging configurations physically block moisture ingress, guaranteeing a 36-month shelf life in Zone IVb high-humidity export climates.
Manufacturing Authority & Compliance
Dedicated Antiviral Containment: Adefovir is a highly potent active antiviral agent. Our manufacturing process utilizes Dedicated Solid Dosage Lines with Negative-Pressure Cleanrooms (HVAC), physically ensuring absolute zero cross-contamination with other drug classes—a vital parameter for international B2B audit compliance.
Moisture-Controlled Synthesis: Adefovir Dipivoxil is chemically unstable and highly prone to hydrolysis when exposed to moisture. We maintain strict Dehumidified Production Suites (Relative Humidity less than 25%) during the blending, compression, and final foil blister-sealing stages.
Kinetic Bioavailability Matching: Every export batch physically undergoes Comparative Dissolution Profiling, chemically ensuring that our generic tablets match the exact bioavailability and clearance curve of the global innovator standard (Hepsera).
Primary Indications
Hepatology: Treatment of Chronic Hepatitis B Virus (HBV) Infection in adults with evidence of active viral replication and either persistent elevations in serum aminotransferases ($ALT$/$AST$) or histologically active liver disease.
Resistance Management: Frontline salvage therapy for patients presenting with confirmed Lamivudine-resistant HBV strains.
Usage Instructions
Administration: Swallow the tablet physically whole with a full glass of water. It can be taken consistently with or without food.
Chronicity & Adherence: It is physically critical to take this medication at the exact same time every day. Missing doses physically increases the risk of the virus developing chemical resistance, destroying future therapeutic options.
Renal Monitoring: Because the drug is chemically cleared via the kidneys, regular Serum Creatinine and Renal Clearance monitoring is physically mandatory before and during treatment.
Safety Warning: POTENT SYSTEMIC ANTIVIRAL. For Gastroenterology/Infectious Disease Specialist Supervision Only. Renal Warning: Chronic administration may physically induce Nephrotoxicity; dosage must be chemically adjusted in patients with pre-existing renal impairment. Lactic Acidosis: Rare but severe physical risk of lactic acidosis and severe hepatomegaly with steatosis. Exacerbation Note: Stopping treatment abruptly can physically cause a severe, life-threatening acute exacerbation of Hepatitis B. Contraindication: Do not use in patients with known hypersensitivity to Adefovir Dipivoxil or any component of the tablet matrix.
Global Export & Contract Manufacturing (CDMO Services)
Healthy Life Pharma Private Limited provides complete, internationally validated Third-Party Contract Manufacturing (CDMO) and private-label production for generic Adefovir Dipivoxil Tablets. Whether you are executing a National Ministry of Health Tender in West Africa, supplying a liver-care clinic infrastructure in the CIS, or injecting inventory into an international B2B Pharma Marketplace in South-East Asia or LATAM, we prepare all required regulatory documentation (WHO-GMP Certificate, Certificate of Pharmaceutical Product – COPP, Certificate of Analysis – COA, and complete CTD Format Dossier sets) for rapid global registration.
Commercial & Bulk Procurement Inquiries:
Corporate Head Office: Mumbai, Maharashtra, India
Primary Manufacturing Base: Boisar, Maharashtra, India
WhatsApp / Direct Call: +91 7710003340
Corporate Email: info@healthyinc.co.in
