In the pharmaceutical industry, Salbutamol (also known as Albuterol) is a short-acting $\beta_2$-adrenergic agonist. As a pharmacist and manufacturer, I must emphasize that while Salbutamol tablets are common in certain export markets, they have largely been superseded by inhalers due to the higher risk of systemic side effects (like tremors and palpitations) when taken orally.
Standard Daily Dosage
For a healthy adult, the typical dosage for Salbutamol tablets (usually 2 mg or 4 mg) is:
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Total Daily Limit: Generally 16 mg to 32 mg per day, divided into multiple doses.
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Single Dose: Usually 2 mg to 4 mg, taken 3 to 4 times a day.
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Maximum Single Dose: In some cases, a doctor may increase a single dose to 8 mg, but only if lower doses are ineffective and the patient tolerates the side effects well.
Mechanism of Action: Bronchodilation
Salbutamol works by targeting the smooth muscles of the airways to facilitate easier breathing.
Selective Binding: It binds to $\beta_2$-adrenoceptors in the bronchial smooth muscle.
cAMP Activation: This binding activates the enzyme adenyl cyclase, which increases levels of cyclic AMP ($cAMP$).
Muscle Relaxation: The increase in $cAMP$ leads to the relaxation of the smooth muscles in the lungs, opening the airways (bronchodilation).
Systemic Effect: Because tablets are systemic (absorbed into the bloodstream), the drug also hits $\beta_2$ receptors in the skeletal muscle and $\beta_1$ receptors in the heart, which is why oral tablets cause more “shaking hands” and “racing heart” than inhalers.
The Manufacturer’s Perspective: Technical & Export
From a production and B2B standpoint at your WHO-GMP facility in Mumbai, Salbutamol tablets are a high-volume “Essential Medicine”:
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The 2 mg vs. 4 mg Strategy: As a firm owner, you should know that the 2 mg tablet is often preferred for geriatric and pediatric patients to minimize “Salbutamol tremors.” On your digital platform, offering both strengths with central scoring for easy half-dosing is a major USP.
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Stability & Shelf Life: Salbutamol is relatively stable but sensitive to light. We utilize Alu-Alu or Amber-colored PVC/PVDC blisters to ensure a 36-month shelf life, which is critical for government tenders and export to Zone IVb regions.
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Combination Potential: Many B2B buyers in Southeast Asia and Africa look for Salbutamol + Bromhexine or Salbutamol + Guaiphenesin combinations. Featuring these Fixed-Dose Combinations (FDCs) on your marketplace can significantly increase your trade volume.
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Dossier Support: This molecule is a staple in international health tenders. We provide full CTD/eCTD Dossiers to support your firm in registering this as a reliable generic against the innovator (Ventolin).