Telmisartan & Metoprolol (Extended-Release) Tablets

Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, antihypertensive, and post-myocardial infarction therapeutics. We provide ultra-high-purity, kinetically segregated Telmisartan (40 mg) & Metoprolol Succinate (25 mg Extended-Release) Tablets, manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “First-Line Cardioprotective Synergy” is a massive-volume, priority export to cardiology centers, primary care networks, hypertension clinics, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the globally mandated initiation therapy for hypertension accompanied by angina or an elevated resting heart rate.

Product Overview

This highly advanced Fixed-Dose Combination (FDC) perfectly balances the longest-acting Angiotensin II Receptor Blocker (ARB) with a highly tolerable, low-dose cardioselective beta-blocker.

The “Hemodynamic Initiation & Tolerability” Specialist:

• Mechanism 1 (The Afterload Reducer – Telmisartan 40mg): At the standard 40mg dose, Telmisartan powerfully blocks the AT1 receptors on blood vessels. This creates sustained vasodilation, dropping the resistance (afterload) the heart must pump against, while shielding the kidneys and improving cellular insulin sensitivity.
• Mechanism 2 (The Heart Rate Controller – Metoprolol 25mg): Metoprolol Succinate acts directly on the heart muscle. By selectively blocking Beta-1 adrenergic receptors, it slows the resting heart rate and reduces the force of cardiac contractions. The 25mg micro-dose is specifically engineered to provide this cardioprotective shield without causing the severe fatigue or dangerous drops in heart rate (bradycardia) sometimes seen with higher doses.
• The 24-Hour Kinetic Advantage: The 25mg Metoprolol Succinate component utilizes an advanced Extended-Release (ER) matrix. This ensures the beta-blocker slowly leaches into the system over 24 hours, perfectly matching the naturally long 24-hour half-life of Telmisartan. This eliminates sudden spikes in heart rate and provides smooth, continuous, round-the-clock protection with a single daily pill.

Product Composition & Strength

We supply this product as a Precision-Engineered Bilayer Film-Coated Tablet, packed exclusively in highly secure, moisture-resistant Alu-Alu blister strips to ensure the absolute stability of both the hygroscopic ARB and the kinetic polymer matrix.

*Pack Sizes: 10×10 or 10×15 Alu-Alu Blisters (Optimized specifically for strict 30-day chronic cardiology adherence regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Cardiology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Alkaline-Polymer Segregation Engineering: Telmisartan requires highly alkaline stabilizers to dissolve, which can rapidly degrade the sustained-release polymers of Metoprolol if mixed together. Our facilities utilize advanced Bilayer Tablet Pressing Technology to physically separate the two active ingredients. This prevents cross-reactivity during shelf life and ensures the Metoprolol component releases smoothly over 24 hours without premature “dose dumping.”

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of cardiovascular strain:

• Essential Hypertension: First-line or step-up treatment of high blood pressure, particularly in patients experiencing stress-induced tachycardia (rapid heart rate) alongside hypertension.
• Stable Angina & Ischemic Heart Disease: Prophylactic management of angina pectoris and reduction of myocardial oxygen demand in patients requiring simultaneous blood pressure control.

Dosage & Administration

Recommended Dosage (Strictly as per Cardiologist Guidelines):

• Standard Adult Dosing: One tablet taken orally once daily, ideally in the morning to blunt the early-morning surge in blood pressure and heart rate.
• Swallowing Protocol (CRITICAL): Because the Metoprolol component is formulated for Extended-Release, the tablet MUST be swallowed whole with a glass of water. Crushing, chewing, or splitting the tablet destroys the delayed-release matrix, causing a rapid, dangerous spike of the beta-blocker in the bloodstream.
• Administration: Can be taken with or without food.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX WARNING (Fetal Toxicity): The Telmisartan component can cause catastrophic injury and death to the developing fetus. Strictly contraindicated in pregnancy.
• Abrupt Withdrawal Warning: This medication MUST NEVER be stopped abruptly. Sudden discontinuation of Metoprolol can trigger a massive surge in catecholamines, leading to severe rebound hypertension, acute angina, or fatal ventricular arrhythmias. It must be tapered slowly.
• Masking of Hypoglycemia: Beta-blockers can mask the warning signs of low blood sugar (such as a rapid heartbeat) in diabetic patients.
• Asthma Caution: While Metoprolol is cardioselective at low doses (like 25mg), caution should still be exercised in patients with asthma or severe COPD, as beta-blockers can trigger bronchospasm.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Cardiovascular FDCs, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for hypertension programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.