Sulfamethoxazole & Trimethoprim Oral Suspension (200 mg + 40 mg)
Healthy Inc is a specialized global supplier and exporter of advanced anti-infectives, pediatric medicine, and public health therapeutics. We provide ultra-high-purity, kinetically stabilized Co-trimoxazole Suspension, manufactured in WHO–GMP certified, high-precision liquid manufacturing facilities. This “Synergistic Sulfonamide & Pyrimidine” combination is a massive-volume strategic export to retail pharmacies, community health centers, and government health ministries, serving as the globally preferred intervention for the treatment of urinary tract infections, respiratory infections, and opportunistic infections in children.
Product Overview
This formulation operates as a “Sequential Metabolic Disruptor.” It physically starves the bacteria of the folic acid it needs to replicate its DNA.
Mechanism 1 (Dihydropteroate Synthase Inhibition – Sulfamethoxazole): A sulfonamide that physically competes with PABA to block the first step of bacterial folate synthesis.
Mechanism 2 (Dihydrofolate Reductase Inhibition – Trimethamine): Physically binds to the second enzyme in the pathway, chemically ensuring that even if some precursor is made, it cannot be converted into active DNA-building blocks.
Mechanism 3 (Synergistic Bactericidal Action): While each drug alone is bacteriostatic (stops growth), the combination is physically Bactericidal (kills bacteria) due to the complete blockade of the folate pathway.
Product Composition & Strength
We supply this product as a Sterile, Homogeneous, Micronized Suspension, optimized for stability and high pediatric compliance.
| Active Ingredient | Strength (per 5ml) | Primary Clinical Function |
| Sulfamethoxazole IP/BP | 200 mg | The Enzyme Blocker 1: Interrupts early folate synthesis. |
| Trimethoprim IP/BP | 40 mg | The Enzyme Blocker 2: Blocks late-stage DNA building. |
| Excipients | Xanthan Gum / Sorbitol | The Matrix: Ensures uniform suspension and dosing. |
| Flavoring | Mixed Fruit / Raspberry / Cherry | The Palatable Base: Essential for child acceptance. |
Technical & Logistics Specifications
HS Code: 3004.20.19 (Medicaments containing other antibiotics)
CAS Numbers: 723-46-6 (Sulfamethoxazole) / 738-70-5 (Trimethoprim)
Dosage Form: Oral Liquid (Suspension)
Packaging: 50ml / 60ml / 100ml Amber PET or Glass Bottles. Our specialized packaging ensures 36-month stability in Zone IVb tropical climates.
Manufacturing Authority & Compliance
Micronized Homogenization: Both actives are physically insoluble. Our manufacturing process utilizes High-Shear Homogenization to ensure a perfectly smooth suspension, preventing “caking” at the bottom of the bottle.
Aseptic Liquid Filling: We utilize Automated Liquid Filling Lines with 100% microbial testing to ensure total safety for immunocompromised patients.
pH Precision: We utilize Advanced Buffering Systems to ensure the chemical integrity of the Sulfonamide molecule throughout its shelf life.
Primary Indications
Pediatrics: Treatment of Acute Otitis Media (Ear infections) and Urinary Tract Infections (UTI).
Public Health: Prophylaxis and treatment of Pneumocystis jirovecii pneumonia (PCP) in HIV-exposed infants.
Respiratory: Management of shigellosis and traveler’s diarrhea in children.
Dermatology: Treatment of certain skin and soft tissue infections.
Dosage & Administration
Children (over 2 months): Typically 8 mg/kg Trimethoprim and 40 mg/kg Sulfamethoxazole daily in two divided doses.
Administration: For maximum safety, it should physically be taken with food and plenty of water to prevent crystalluria.
Shake Well: The bottle must be physically shaken before each use to ensure uniform drug distribution.
Safety Warning: For Oral Use Only. Hydration Note: Patients must physically drink plenty of fluids to prevent sulfonamide crystals in the kidneys. Skin Warning: Immediately discontinue if any Skin Rash occurs (risk of Stevens-Johnson Syndrome). Contraindication: Do not use in infants under 2 months of age, patients with severe renal or hepatic failure, or those with known hypersensitivity to Sulfonamides.
Global Export & Contract Manufacturing
Healthy Inc is a premier Anti-Infective and Pediatric Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-volume Co-trimoxazole suspensions. Whether you are a National HIV/AIDS Program in Africa or a B2B Pharma Marketplace partner in the CIS or SE Asia, we ensure secure, WHO-GMP compliant delivery.