Ramipril & Hydrochlorothiazide Tablets (5 mg / 12.5 mg & 5 mg / 25 mg)

Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, anti-hypertensive, and critical-care therapeutics. We provide ultra-high-purity, kinetically stabilized Ramipril & Hydrochlorothiazide (HCTZ) Film-Coated Tablets / Hard Capsules, manufactured in WHO–GMP certified, strictly humidity-controlled oral solid dosage facilities. This “ACE Inhibitor & Thiazide Diuretic Synergy” is a massive-volume, essential export to cardiology centers, general practice clinics, retail pharmacy networks, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally trusted, first-line intervention for the rapid and sustained control of Essential Hypertension.

Product Overview

This highly advanced Fixed-Dose Combination masterfully synchronizes a highly tissue-penetrating ACE inhibitor with the world’s most prescribed thiazide diuretic, delivering unparalleled, dual-pathway blood pressure reduction while actively neutralizing metabolic side effects.

The “Volume Reduction & Potassium Balance” Specialist:

• Mechanism 1 (The Volume Reducer – HCTZ 12.5mg/25mg): Hydrochlorothiazide works directly on the kidneys (specifically the distal convoluted tubule). It forces the kidneys to excrete sodium and water into the urine. By physically reducing the volume of fluid in the bloodstream, the pressure against the artery walls drops significantly. However, diuretics alone cause the body to panic and activate the RAAS (Renin-Angiotensin-Aldosterone System) to raise blood pressure back up.
• Mechanism 2 (The RAAS Blocker – Ramipril 5mg): This is where the synergy occurs. Ramipril aggressively blocks the RAAS that the diuretic just triggered. By stopping the production of Angiotensin II, it forces the blood vessels to relax and dilate, compounding the blood pressure drop.
• The “Potassium-Sparing” Advantage (CRITICAL CLINICAL BENEFIT): When used alone, HCTZ causes dangerous amounts of potassium to be flushed out in the urine (Hypokalemia), leading to severe muscle cramps and cardiac arrhythmias. Ramipril solves this perfectly. By suppressing aldosterone, Ramipril forces the body to retain potassium. The two drugs perfectly cancel out each other’s metabolic side effects, creating a highly stable, long-term cardiovascular therapy.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Cardiology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Alkaline Micro-Environment Engineering: Formulating Ramipril alongside HCTZ is exceptionally difficult due to Ramipril’s high susceptibility to hydrolytic and mechanical stress during compression. Our facilities utilize advanced dry-blending techniques and incorporate specialized alkaline stabilizers (like Sodium Bicarbonate) to create a micro-pH environment within the tablet matrix. This completely prevents the Ramipril from degrading over the product’s multi-year shelf life.

Therapeutic Indications (Human Use)

Indicated for the targeted, multi-pathway management of severe cardiovascular disease:

• Essential Hypertension: Treatment of essential hypertension in patients whose blood pressure is not adequately controlled on Ramipril or Hydrochlorothiazide alone, or as substitution therapy for patients already controlled on the individual components given concurrently.

Dosage & Administration

Recommended Dosage (Strictly as per Physician Guidelines):

• Standard Adult Dosing: One tablet (e.g., 5mg/12.5mg) taken orally once daily.
• Administration (THE MORNING RULE): Because HCTZ is a diuretic that forces the patient to urinate frequently, this medication MUST be taken in the morning. Taking it at night will cause severe sleep disruption (nocturia). Tablets must be swallowed whole with fluid.
• Renal Impairment: Thiazide diuretics are ineffective in patients with severe renal impairment (Creatinine Clearance < 30 mL/min). This FDC is strictly contraindicated in these patients.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX WARNING (Fetal Toxicity): When pregnancy is detected, discontinue this medication immediately. Drugs that act directly on the renin-angiotensin system (Ramipril) can cause profound injury, massive malformations, and death to the developing fetus.
• Non-Melanoma Skin Cancer (HCTZ Photosensitivity): Long-term, continuous use of Hydrochlorothiazide increases the risk of non-melanoma skin cancer (basal cell and squamous cell carcinoma) due to its strong photosensitizing properties. Patients must be advised to use high-SPF sunscreen and limit extreme sun exposure.
• The ACE Inhibitor Dry Cough: Ramipril prevents the breakdown of bradykinin in the lungs, potentially causing a chronic, persistent, non-productive dry cough.
• Metabolic Shifts: HCTZ can impair glucose tolerance (increasing blood sugar in diabetics) and raise uric acid levels (potentially triggering painful gout attacks).

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Cardiovascular Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Government Tender Supplier for hypertension clinics in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.