Piroxicam Tablets / Capsules (10 mg / 20 mg)

Healthy Inc is a specialized global supplier and exporter of advanced rheumatological, orthopedic, and chronic pain management therapeutics. We provide ultra-high-purity, kinetically stabilized Pramipexole Uncoated / Film-Coated Tablets (10 mg / 20 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Long-Acting Oxicam NSAID” is a massive-volume, highly lucrative export to orthopedic centers, rheumatology clinics, retail pharmacy networks, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, once-daily intervention for the severe, relentless inflammation of Osteoarthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis.

Product Overview

This highly advanced formulation contains Pramipexole, a highly potent, long-acting nonsteroidal anti-inflammatory drug (NSAID) that fundamentally outperforms short-acting painkillers by delivering constant, unbroken 24-hour suppression of inflammatory joint destruction.

The “Once-Daily Oxicam” Specialist:

• Mechanism 1 (The COX-1 / COX-2 Blockade): In severe arthritis, the body’s immune system mistakenly attacks the joints, triggering the Cyclooxygenase (COX) enzymes to produce massive amounts of prostaglandins. These prostaglandins cause severe swelling, heat, and agonizing bone-on-bone pain. Piroxicam aggressively and non-selectively blocks both COX-1 and COX-2 enzymes, rapidly shutting down prostaglandin synthesis right at the site of the joint capsule.
• Mechanism 2 (The 50-Hour Half-Life Advantage): Standard NSAIDs like Ibuprofen wear off in 4 to 6 hours, causing the patient to wake up in the middle of the night in extreme pain (“morning stiffness”). Piroxicam has a massive, prolonged half-life of approximately 50 hours. A single tablet builds a highly stable, continuous concentration of the drug in the bloodstream and the synovial fluid of the joints, guaranteeing unbroken, 24-hour mobility and eliminating morning stiffness.
• The White Blood Cell Suppressor: Beyond just blocking enzymes, Piroxicam has a unique secondary mechanism: it actively inhibits the migration of neutrophils and other destructive white blood cells into the inflamed joint space, preventing them from releasing toxic free radicals that permanently destroy cartilage.

Product Composition & Strength

We supply this product as a Precision-Blended Tablet or Hard Gelatin Capsule, packed exclusively in highly secure, moisture-resistant Alu-Alu or high-density PVC/PVDC blister strips to ensure the absolute chemical stability of the highly insoluble active ingredient.

*Pack Sizes: 10×10 Blisters (Optimized specifically for strict 30-day chronic rheumatology and orthopedic dispensing regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Orthopedic Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Insoluble API Granulation Engineering: Piroxicam is practically insoluble in water and gastric fluids. If manufactured poorly, the tablet will pass through the patient’s digestive tract without absorbing, leading to total clinical failure. Our facilities utilize advanced high-shear wet granulation combined with specialized pharmaceutical surfactants (like SLS). This drastically increases the surface area and wettability of the API, guaranteeing rapid, total absorption and flawless clinical bioequivalence.

Therapeutic Indications (Human Use)

Indicated for the targeted management of severe, chronic inflammatory and musculoskeletal dysfunction:

• Rheumatoid Arthritis (RA) & Osteoarthritis (OA): Symptomatic relief of severe pain, joint stiffness, and inflammation.
• Ankylosing Spondylitis: Management of severe, progressive spinal inflammation and stiffness.
• Acute Gout: Short-term management of acute gouty arthritis attacks (off-label or regional specific).

Dosage & Administration

Recommended Dosage (Strictly as per Rheumatologist Guidelines):

• Standard Adult Dosing: 20 mg taken orally once daily. (Alternatively, 10 mg twice daily, though once-daily is the clinical standard for compliance).
• Administration (THE MEALTIME RULE – CRITICAL): To drastically reduce the risk of severe gastric ulceration and gastrointestinal bleeding, the tablet MUST be taken immediately after a heavy meal with a full glass of water. It should never be taken on an empty stomach.
• The 20 mg Limit: The total daily dose must never exceed 20 mg. Doses higher than 20 mg do not provide additional pain relief but exponentially increase the risk of catastrophic gastrointestinal hemorrhage.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX WARNING (Cardiovascular Thrombosis): Like all NSAIDs, Piroxicam may cause an increased risk of serious, fatal cardiovascular thrombotic events, myocardial infarction (heart attack), and stroke. It is strictly contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
• BLACK BOX WARNING (Gastrointestinal Bleeding): Piroxicam has one of the highest risks of severe, fatal gastrointestinal bleeding, ulceration, and perforation among all NSAIDs. It is heavily recommended to co-prescribe a gastro-protective agent (like Rabeprazole or Famotidine) for patients on chronic Piroxicam therapy, especially the elderly.
• Severe Skin Reactions (SJS/TEN): Piroxicam is associated with an increased risk of severe, potentially fatal skin reactions, including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Discontinue immediately at the first sign of a skin rash or mucosal lesions.
• Renal Toxicity: Long-term administration can result in renal papillary necrosis and chronic kidney disease. Hydration must be maintained.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Rheumatological and Pain Management Formulations. Whether you are looking for a reliable Government Tender Supplier for orthopedic clinics in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery of WHO-GMP certified products.