Perindopril Erbumine Tablets (2 mg / 4 mg / 8 mg)
Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, anti-hypertensive, and post-myocardial infarction therapeutics. We provide ultra-high-purity, kinetically stabilized Perindopril Erbumine Tablets (2 mg / 4 mg / 8 mg), manufactured in WHO–GMP certified, strictly humidity-controlled oral solid dosage facilities. This “Tissue-Penetrating ACE Inhibitor” is a massive-volume, premium export to cardiology centers, internal medicine clinics, retail pharmacy networks, and government health ministries in Francophone Africa, the CIS, LATAM, and Southeast Asia, serving as the globally mandated intervention for severe Essential Hypertension, Heart Failure, and the prevention of cardiovascular events in patients with stable coronary artery disease.
Product Overview
This highly advanced formulation contains Perindopril (as Erbumine), a long-acting prodrug that metabolizes into the highly potent perindoprilat. It acts as an elite, lipophilic shield for the cardiovascular system, delivering unparalleled 24-hour blood pressure control while actively reversing damage to the heart and blood vessels.
The “Endothelial Healer & 24-Hour ACE” Specialist:
- Mechanism 1 (The RAAS Blockade): Perindopril aggressively inhibits the Angiotensin-Converting Enzyme (ACE). This prevents the body from producing Angiotensin II, a potent chemical that forcefully constricts blood vessels and forces the kidneys to retain salt and water. By shutting this down, Perindopril physically relaxes the arterial walls, dropping peripheral vascular resistance and profoundly reducing the workload on a failing heart.
- Mechanism 2 (High Tissue Affinity & Plaque Stabilization): Unlike older, water-soluble ACE inhibitors (like Lisinopril), Perindopril is highly lipophilic (fat-soluble). It doesn’t just float in the blood; it physically penetrates deep into the tissues of the heart and the endothelial lining of the arteries. Here, it actively prevents the breakdown of bradykinin, which stimulates the release of Nitric Oxide (a powerful vasodilator). This action actively stabilizes dangerous atherosclerotic plaques, drastically reducing the risk of a sudden heart attack.
- The True 24-Hour Trough-to-Peak Ratio: Perindoprilat possesses an exceptionally long terminal half-life. A single morning dose guarantees smooth, unbroken blood pressure control for a full 24 hours, completely preventing the dangerous, early-morning spikes in blood pressure that cause most ischemic strokes.
Product Composition & Strength
We supply this product as a Precision-Blended Uncoated Tablet, packed exclusively in highly secure, moisture-resistant Alu-Alu blister strips equipped with active desiccants to ensure the absolute chemical stability of the highly degradable Erbumine salt.
| Active Ingredient | Strength | Primary Clinical Function |
|---|---|---|
| Perindopril Erbumine Ph.Eur./USP | 2 mg | Initiation Standard: Base titration dose for elderly patients or those with severe heart failure/renal impairment to prevent sudden hypotension. |
| Perindopril Erbumine Ph.Eur./USP | 4 mg | Hypertension Standard: Standard adult maintenance dose for the continuous control of essential hypertension. |
| Perindopril Erbumine Ph.Eur./USP | 8 mg | Cardiovascular Risk Standard: Maximum maintenance dose for profound risk reduction in patients with stable coronary artery disease. |
| Excipients | Microcrystalline Cellulose / Lactose Anhydrous / Hydrophobic Colloidal Silica / Magnesium Stearate | Diluent / Alkaline Stabilizer / Moisture Scavenger / Lubricant (Engineered specifically to create a hyper-dry internal tablet matrix that absolutely prevents hydrolytic cyclization of the API) |
*Pack Sizes: 10×10 Alu-Alu Blisters or 3×10 Unit-Dose Blisters (Optimized specifically for strict 30-day chronic cardiology dispensing regimens).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers, Cardiology Distributors, and Hospital Procurement Boards.
| HS Code | 3004.90.99 (Medicaments containing other active substances – Cardiovascular/Antihypertensives) |
| CAS Number | 107133-36-8 (Perindopril Erbumine) |
| Dosage Form | Tablet (Immediate Release Prodrug) |
| Packaging | Alu-Alu Blisters (STRICTLY MANDATORY). Perindopril Erbumine is violently unstable when exposed to moisture and heat, rapidly degrading into inactive diketopiperazine. Heavy-gauge Alu-Alu packaging guarantees absolute chemical stability and full therapeutic potency across Zone IVb tropical climates. |
| Storage | Store strictly below 25°C in a dry place. Protect heavily from Moisture. |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Alkaline Micro-Environment & Dry-Granulation Engineering: Manufacturing Perindopril is a severe test of a facility’s quality control. If any water is introduced during granulation, the product is ruined. Our facilities completely bypass wet granulation, utilizing advanced dry-blending in ultra-low humidity suites (RH < 25%). We incorporate anhydrous excipients and specialized alkaline stabilizers to create a micro-pH environment within the tablet, locking the Perindopril molecule into its stable state and guaranteeing a flawless multi-year shelf life.
Therapeutic Indications (Human Use)
Indicated for the comprehensive, multi-pathway management of severe cardiovascular disease:
- Essential Hypertension: Treatment of high blood pressure as a once-daily monotherapy or in combination with other antihypertensive classes (e.g., Amlodipine or Indapamide).
- Stable Coronary Artery Disease: Reduction of the risk of cardiovascular events in patients with a history of myocardial infarction and/or revascularization.
- Congestive Heart Failure: Treatment of symptomatic heart failure, specifically to reduce mortality and hospitalization.
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist Guidelines):
- Standard Adult Dosing: Initially 4 mg once daily in the morning. After one month, this may be increased to 8 mg once daily based on clinical response.
- Administration (THE EMPTY STOMACH RULE – CRITICAL): Perindopril is a prodrug. Food in the stomach drastically alters the gastric pH and severely reduces the conversion of Perindopril into the active perindoprilat by up to 35%. The tablet MUST be taken in the morning before a meal (on an empty stomach) with a glass of water.
- Renal Impairment: Because the active metabolite is cleared by the kidneys, the dose must be strictly reduced based on creatinine clearance.
Safety Warnings (CRITICAL Regulatory & Clinical Data):
- BLACK BOX WARNING (Fetal Toxicity): When pregnancy is detected, discontinue this medication immediately. Drugs that act directly on the renin-angiotensin system can cause profound injury, massive malformations, and death to the developing fetus.
- Angioedema Risk (Facial/Airway Swelling): ACE inhibitors can cause sudden, life-threatening swelling of the face, lips, tongue, and airway (angioedema) at any time during therapy, requiring immediate emergency intubation and epinephrine.
- The Bradykinin Dry Cough: Because Perindopril prevents the breakdown of bradykinin in the lungs, it can cause a chronic, persistent, non-productive dry cough. If intolerable, the patient must be switched to an ARB.
- Hyperkalemia: Perindopril forces the body to retain potassium. Concurrent use of potassium-sparing diuretics (like Spironolactone) or potassium supplements can lead to fatal cardiac arrhythmias.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Cardiovascular Formulations. Whether you are looking for a reliable Government Tender Supplier for cardiology clinics in Francophone Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely, secure delivery of highly stable, WHO-GMP certified products.