Memantine Hydrochloride Film-Coated Tablets (5 mg / 10 mg)
Healthy Inc is a specialized global supplier and exporter of advanced neurology, geriatric-support, and neuroprotective therapeutics. We provide ultra-high-purity, kinetically precise Memantine Hydrochloride Film-Coated Tablets (5 mg / 10 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “NMDA Receptor Antagonist” is a massive-volume, highly lucrative export to neurology centers, memory care institutes, geriatric hospital networks, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, neuroprotective intervention for moderate to severe Alzheimer’s disease and vascular dementia.
Product Overview
This highly advanced formulation fundamentally alters the destructive chemical environment of the degenerating brain. It acts as an intelligent “bouncer” for brain cells, blocking the toxic neurological noise that kills neurons while allowing the vital signals required for memory and learning to pass through intact.
The “Glutamate Blocker & Neuroprotective” Specialist:
- Mechanism 1 (The Excitotoxicity Shield): In Alzheimer’s disease, diseased brain cells leak massive, continuous amounts of a neurotransmitter called glutamate. This constant glutamate triggers the NMDA receptors to stay locked open, flooding the neurons with lethal amounts of calcium. This calcium overload literally burns the brain cell to death (excitotoxicity). Memantine is an uncompetitive NMDA receptor antagonist. It physically plugs the open receptor, violently halting the toxic calcium flood and keeping the neuron alive.
- Mechanism 2 (The “Low-Affinity” Advantage): If you permanently block the NMDA receptor (like Ketamine does), the patient hallucinates and goes into a coma. Memantine is brilliantly engineered with “low affinity.” It only blocks the receptor during the constant, pathological background noise of Alzheimer’s. When a real, physiological memory signal fires, Memantine detaches for a millisecond, lets the memory form, and then re-plugs the hole. It protects the brain without paralyzing it.
- The Donepezil Synergy: Memantine is almost universally prescribed alongside an Acetylcholinesterase Inhibitor (like Donepezil). While Donepezil boosts the remaining memory chemicals, Memantine stops the underlying cell death. Together, they form the globally recognized “Dual-Action Cognitive Shield” that keeps dementia patients out of nursing homes for as long as possible.
Product Composition & Strength
We supply this product as a Precision-Blended, High-Density Film-Coated Tablet, packed exclusively in highly secure, moisture-resistant Alu-PVC or Alu-Alu blister strips, frequently customized into 4-week Titration Starter Packs.
| Active Ingredient | Strength | Primary Clinical Function |
|---|---|---|
| Memantine (as Hydrochloride) USP/Ph.Eur. | 5 mg | Initiation / Titration Standard: Base therapeutic unit utilized exclusively for the mandatory 4-week step-up protocol to build patient tolerance and prevent severe CNS adverse effects. |
| Memantine (as Hydrochloride) USP/Ph.Eur. | 10 mg | Global Neurology Standard: High-efficacy adult maintenance dose, typically taken twice daily, for the sustained neuroprotection of the degenerating brain. |
| Excipients | Microcrystalline Cellulose / Lactose Monohydrate / Croscarmellose Sodium / Magnesium Stearate / Premium Opadry Film | Diluent / Binder / Superdisintegrant / Slipper-Coating (Engineered specifically with a heavy, smooth film-coat to ensure immediate gastric transit and absolute ease of swallowing for elderly patients suffering from severe dysphagia) |
*Pack Sizes: 10×10 Blisters, Bottles of 60, or Customized 28-Day Titration Starter Kits (Optimized specifically for strict chronic geriatric dispensing regimens).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers, Neurology Distributors, and Hospital Procurement Boards.
| HS Code | 3004.90.99 (Medicaments containing other active substances – Neurology/Anti-Dementia) |
| CAS Number | 41100-52-1 (Memantine Hydrochloride) |
| Dosage Form | Film-Coated Tablet (Immediate Release) |
| Packaging | High-Density Alu-PVC or Alu-Alu Blisters. Protects the formulation from environmental humidity across Zone IVb tropical climates. (Titration packs are heavily color-coded by week to prevent fatal caregiver dosing errors). |
| Storage | Store strictly below 30°C in a dry place. Protect from Moisture. |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Geriatric Compliance & Titration Packaging Engineering (CRITICAL COMPLIANCE): The biggest cause of clinical failure with Memantine is poor caregiver compliance during the initiation phase. If the patient takes 20mg on Day 1, they will suffer severe dizziness, falls, and hallucinations. Our facilities utilize advanced blister-packing technology to offer fully printed, day-by-day Titration Kits (Week 1: 5mg, Week 2: 10mg, Week 3: 15mg, Week 4: 20mg). By providing idiot-proof visual guides for stressed caregivers, we guarantee flawless dose escalation and total patient safety.
Therapeutic Indications (Human Use)
Indicated for the targeted, highly specialized management of neurodegenerative disorders:
- Alzheimer’s Disease: Treatment of moderate to severe dementia of the Alzheimer’s type. (Note: Not clinically indicated or effective for *mild* Alzheimer’s).
- Vascular Dementia: Off-label use for cognitive decline resulting from chronic cerebrovascular disease and micro-strokes.
Dosage & Administration
Recommended Dosage (Strictly as per Neurologist Guidelines):
- The Mandatory Titration Protocol:
- Week 1: 5 mg once daily.
- Week 2: 10 mg daily (5 mg twice a day).
- Week 3: 15 mg daily (5 mg morning, 10 mg evening).
- Week 4 & Maintenance: 20 mg daily (10 mg twice a day).
- Administration: Can be taken with or without food.
Safety Warnings (CRITICAL Regulatory & Clinical Data):
- Severe Renal Impairment (Dose Reduction): Memantine is primarily excreted unchanged by the kidneys. In patients with severe renal impairment (creatinine clearance 5 to 29 mL/min), the drug builds up to toxic levels. The target maintenance dose MUST be drastically reduced to 5 mg twice daily (10 mg/day maximum).
- The “Alkaline Urine” Toxicity Warning: The clearance of Memantine is heavily dependent on urine pH. If a patient’s urine becomes highly alkaline (pH > 8) due to severe urinary tract infections, massive dietary changes (extreme vegetarian diets), or drugs like carbonic anhydrase inhibitors, the body stops excreting Memantine. Blood levels can spike by 80%, causing severe neurological toxicity and hallucinations.
- Seizure Disorders: Must be used with extreme caution in patients with a history of seizures or epilepsy, as NMDA modulation can theoretically alter seizure thresholds.
- Paradoxical Confusion: While used to treat dementia, rapid dose escalation can paradoxically cause severe confusion, extreme dizziness, and somnolence, leading to catastrophic hip fractures from falls.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Geriatric Care Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Neurological, Anti-Dementia, and Geriatric-Compliant Formulations. Whether you are looking for a reliable Government Tender Supplier for aging populations in the CIS or a B2B Pharma Marketplace partner for Latin America, our highly regulated logistics network ensures timely, secure delivery of WHO-GMP certified products.