Mefenamic Acid & Dicyclomine Hydrochloride Tablets (250 mg / 10 mg)

Healthy Inc is a specialized global supplier and exporter of advanced women’s health, gastroenterology, and acute pain management therapeutics. We provide ultra-high-purity, kinetically optimized Mefenamic Acid & Dicyclomine Hydrochloride Film-Coated / Uncoated Tablets (250 mg / 10 mg), manufactured in WHO–GMP certified, high-precision rapid-release oral solid dosage facilities. This “Dual-Action Anti-Spasmodic & NSAID FDC” is a massive-volume, highly lucrative export to gynecology centers, general practice networks, retail pharmacy chains, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, rapid-relief intervention for spasmodic dysmenorrhea, intestinal colic, and acute smooth muscle spasms.

Product Overview

This highly advanced Fixed-Dose Combination masterfully synchronizes a unique, dual-acting NSAID with a highly potent antimuscarinic agent. Together, they form an impenetrable shield against severe abdominal and pelvic pain by attacking both the chemical triggers of inflammation and the physical mechanics of muscle cramping.

The “Prostaglandin Blockade & Smooth Muscle Relaxant” Specialist:

• Mechanism 1 (The Mefenamic Acid Dual-Blockade): During menstruation or tissue trauma, the body produces massive amounts of prostaglandins, which cause severe inflammation and pain. Mefenamic acid is a unique NSAID (a fenamate). Not only does it inhibit the COX-1 and COX-2 enzymes to stop the *production* of new prostaglandins, but it also actively blocks existing prostaglandins at the receptor site. This dual-action provides profoundly faster pain relief than standard ibuprofen or diclofenac.
• Mechanism 2 (The Dicyclomine Anticholinergic Strike): While Mefenamic acid handles the inflammation, Dicyclomine directly targets the smooth muscle lining the uterus, stomach, and intestines. It aggressively blocks acetylcholine from binding to muscarinic receptors on these muscles. This completely paralyses the spasm, forcing the violently contracting smooth muscle to instantly relax.
• The Dysmenorrhea & Colic Synergy: Severe menstrual cramps are caused by prostaglandins forcing the uterus into violent, oxygen-starving contractions. By simultaneously cutting off the prostaglandin supply (Mefenamic Acid) and physically relaxing the uterine muscle wall (Dicyclomine), this FDC delivers total, rapid eradication of acute pelvic and abdominal pain within 30 to 45 minutes of ingestion.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Gynecology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• High-Shear Uniformity & Dissolution Engineering (CRITICAL COMPLIANCE): Combining a massive 250mg dose of poorly soluble Mefenamic Acid with a microscopic 10mg dose of Dicyclomine presents a severe content uniformity challenge. If standard blending is used, some pills will lack the antispasmodic entirely. Our facilities utilize advanced high-shear wet granulation to perfectly bind the micro-dosed Dicyclomine to the Mefenamic matrix. Paired with premium superdisintegrants, we guarantee 100% active payload delivery and flawless batch-to-batch consistency.

Therapeutic Indications (Human Use)

Indicated for the targeted, highly aggressive management of acute smooth muscle spasms and inflammatory pain:

• Spasmodic Dysmenorrhea: First-line therapy for severe primary and secondary menstrual cramps and pelvic pain.
• Gastrointestinal & Intestinal Colic: Rapid relief of severe cramping, irritable bowel spasms, and gripping stomach pain.
• Biliary & Renal Colic: Used as a highly effective adjunctive oral therapy to manage the severe, radiating pain of passing kidney stones or gallstones.

Dosage & Administration

Recommended Dosage (Strictly as per Physician Guidelines):

• Standard Adult Dosing: One to two tablets taken orally 3 to 4 times a day, depending on the severity of the spasm.
• Duration Limitation: Therapy should generally not exceed 7 days to prevent NSAID-induced gastric mucosal damage.
• Administration: MUST be taken with food, milk, or a full glass of water to massively reduce the risk of severe gastric irritation and ulceration associated with Mefenamic Acid.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Anticholinergic Toxicity (Dicyclomine): Can cause severe dry mouth, blurred vision, urinary retention, and constipation. It is strictly contraindicated in patients with Glaucoma or severe Benign Prostatic Hyperplasia (BPH).
• Heat Prostration Warning: Dicyclomine completely stops the body from sweating. In extreme tropical climates, taking this medication and working outdoors can lead to rapid, fatal heatstroke.
• BLACK BOX EQUIVALENT (NSAID Cardiovascular & GI Risk): Mefenamic acid carries the standard NSAID risk of serious cardiovascular thrombotic events (myocardial infarction and stroke) and serious gastrointestinal bleeding, ulceration, and perforation.
• Asthma Exacerbation: Strictly contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking Aspirin or other NSAIDs.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Gynecology Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Analgesic, Antispasmodic, and FDC Formulations. Whether you are looking for a reliable Government Tender Supplier for women’s health clinics in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely, secure delivery of highly stable, WHO-GMP certified products.