Losartan Potassium + Hydrochlorothiazide Tablets
Healthy Inc is a specialized global supplier and exporter of synergistic antihypertensive combinations. We provide high-stability Losartan Potassium & Hydrochlorothiazide Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Dual-Action Pressure Control” is a top export to cardiology clinics, hypertension management programs, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the preferred second-line therapy for patients whose blood pressure is not adequately controlled by monotherapy.
Product Overview
This formulation contains a strategic combination of an Angiotensin II Receptor Blocker (ARB) and a Thiazide Diuretic.
The “Complementary Force” Specialist:
- Mechanism (Losartan): Selectively blocks the binding of Angiotensin II to the AT1 receptor in vascular smooth muscle. This prevents vasoconstriction (narrowing of blood vessels) and aldosterone secretion, directly lowering blood pressure.
- Mechanism (Hydrochlorothiazide – HCTZ): Acts on the distal convoluted tubule of the kidney to inhibit the reabsorption of Sodium and Chloride. This promotes the excretion of water (diuresis), reducing plasma volume and cardiac output.
- Synergy: Diuretics often trigger a compensatory release of Renin (activating the RAAS system). Losartan blocks the downstream effect of this renin release. Furthermore, Losartan attenuates the potassium loss often caused by HCTZ, providing a more balanced electrolyte profile.
Product Composition & Strength
We supply this product as Film Coated Tablets (typically Yellow or White, Oval). The coating protects the hygroscopic Losartan from moisture.
| Active Ingredient | Strength (Standard) | Therapeutic Role | |
|---|---|---|---|
| Losartan Potassium USP/BP | 50 mg | Vasodilator (ARB) | |
| Hydrochlorothiazide USP/BP | 12.5 mg | Diuretic (Thiazide) | |
| (High Strength Variant) | 100 mg Losartan + 25 mg HCTZ | Severe Hypertension | |
| Excipients | Q.S. | Microcrystalline Cellulose / Lactose / Magnesium Stearate | Filler / Lubricant |
*Pack Sizes: Blister packs of 10s, 14s, 15s (Calendar Pack), 30s, or Bulk HDPE Jars of 1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Film Coated) |
| Packaging | Alu-Alu Blister (Strictly Moisture Sensitive) |
| Storage | Store below 25°C. Protect strictly from Moisture and Light. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Hygroscopicity Control: Losartan Potassium is extremely hygroscopic (absorbs water rapidly). We manufacture in dehumidified suites (< 30% RH) and use Cold Form Alu-Alu packaging to prevent the tablet from degrading or becoming sticky.
- Dissolution Stability: HCTZ has low solubility. Our formulation uses micronized HCTZ to ensure consistent dissolution and bioavailability alongside the highly soluble Losartan.
Therapeutic Indications (Human Use)
Indicated for the treatment of:
- Essential Hypertension: For patients not adequately controlled on Losartan or Hydrochlorothiazide alone.
- Left Ventricular Hypertrophy (LVH): Reduction of the risk of stroke in patients with hypertension and LVH.
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Adults: One tablet (50/12.5 mg) once daily.
- Titration: If blood pressure remains uncontrolled after 3 weeks, the dose may be increased to 100/25 mg once daily.
- Administration: Can be taken with or without food. Best taken in the morning to prevent nocturia (nighttime urination) caused by the diuretic.
Safety Warnings:
- Fetal Toxicity (BLACK BOX WARNING): CONTRAINDICATED IN PREGNANCY. Drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus. Discontinue as soon as pregnancy is detected.
- Electrolyte Imbalance: Monitor Potassium levels. HCTZ lowers potassium (Hypokalemia), while Losartan raises it (Hyperkalemia). The balance usually neutralizes, but checks are required.
- Renal Function: Use with caution in patients with renal artery stenosis.
- Sulfonamide Allergy: HCTZ is a sulfonamide derivative; avoid in patients with severe sulfa allergies.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.