Etizolam Film-Coated & Mouth Dissolving (MD) Tablets (0.25 mg / 0.5 mg / 1 mg)
Healthy Inc is a specialized global supplier and exporter of advanced psychiatry, neuro-pharmacology, and rapid-onset behavioral therapeutics. We provide ultra-high-purity, kinetically precise Etizolam Film-Coated and Mouth Dissolving (MD) Tablets (0.25 mg / 0.5 mg / 1 mg), manufactured in WHO–GMP certified, high-precision micro-dosing oral solid dosage facilities. This “Thienodiazepine Anxiolytic & Hypnotic” is a massive-volume, highly lucrative export to psychiatric hospitals, acute stress clinics, and government health ministries in approved regions across Southeast Asia, the CIS, and LATAM, serving as the globally recognized, rapid-onset intervention for severe Generalized Anxiety Disorder (GAD), acute panic attacks, and short-term insomnia.
Product Overview
This highly advanced formulation operates as a profound, rapid-acting electrical dampener for the central nervous system. It chemically forces the brain’s hyperactive fear and arousal centers to instantly relax, terminating the catastrophic physical and mental loops of a panic attack within minutes.
The “GABA-A Allosteric Modulator & Thienodiazepine” Specialist:
- Mechanism 1 (The GABA-A Amplification): Etizolam aggressively binds to the allosteric benzodiazepine site on the GABA-A receptor in the central nervous system. When it binds, it massively amplifies the efficiency of GABA (the brain’s primary inhibitory neurotransmitter). This forces chloride ions to flood into the neurons, causing hyperpolarization. The neurons physically cannot fire, instantly shutting down the cascading electrical storm that causes severe anxiety and muscle tension.
- Mechanism 2 (The Thienodiazepine Structural Advantage): Unlike traditional benzodiazepines (like Alprazolam or Diazepam) which have a benzene ring, Etizolam features a thiophene ring. This slight structural shift gives Etizolam a remarkably fast onset of action and a relatively short half-life (approx. 3.5 hours). It acts rapidly to kill a panic attack but clears the system quickly, leaving the patient with vastly less “hangover” lethargy or daytime drowsiness compared to older generation sedatives.
- The “Mouth Dissolving (MD)” Synergy: In the midst of a severe panic attack, a patient often cannot swallow water. Our MD formulations are engineered to instantly dissolve on the tongue or sublingually, bypassing the stomach and absorbing directly through the oral mucosa into the bloodstream for near-instantaneous psychiatric relief.
Product Composition & Strength
We supply this product as a Precision-Blended, High-Density Microdose Tablet, packed exclusively in highly secure, moisture-resistant Alu-Alu blister strips to ensure the absolute chemical stability of the ultra-low-dose API.
| Active Ingredient | Strength | Primary Clinical Function |
|---|---|---|
| Etizolam JP/Ph.Eur. | 0.25 mg | The Geriatric & Daytime Standard: The definitive ultra-low-dose unit utilized for daytime anxiety suppression without severe sedation, or for highly sensitive elderly patients. |
| Etizolam JP/Ph.Eur. | 0.5 mg / 1 mg | The Panic & Insomnia Standard: High-efficacy therapeutic payload utilized for the immediate termination of acute panic attacks and the induction of sleep in severe insomnia. |
| Excipients (MD Formulation) | Mannitol / Crospovidone / Aspartame / Peppermint Flavor / Magnesium Stearate | Diluent / Superdisintegrant / Sweetener / Flavoring (Engineered specifically using elite “Rapid-Burst” superdisintegrants to ensure the tablet shatters and dissolves in saliva within seconds, masking the chemical taste for maximum patient compliance during severe distress) |
*Pack Sizes: 10×10 Alu-Alu Blisters (Optimized specifically for strict, short-term psychiatric dispensing regimens).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers, Psychiatric Distributors, and Hospital Procurement Boards.
| HS Code | 3004.90.99 (Medicaments containing other active substances – Psychiatry/Anxiolytics) |
| CAS Number | 40054-69-1 (Etizolam) |
| Dosage Form | Film-Coated Tablet OR Mouth Dissolving (MD) Tablet |
| Packaging | High-Density Alu-Alu Blisters (STRICTLY MANDATORY). MD formulations are intensely hygroscopic. Standard packaging will cause the tablet to turn into a paste. Strict barrier packaging guarantees physical integrity across Zone IVb tropical climates. |
| Export Compliance | Highly Controlled Psychotropic Substance. Export is strictly subject to the issuance of an Import Certificate from the destination country’s Ministry of Health and a corresponding Narcotic Export Authorization from the manufacturing state. |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Ultra-Microdose Content Uniformity & MD Engineering (CRITICAL COMPLIANCE): The clinical safety of Etizolam dictates absolute blending perfection. If a patient accidentally ingests a 1.5 mg “hot spot” due to poor factory blending, they could suffer severe respiratory depression. Our psychiatric suites utilize elite geometric dry-blending and intensive HPLC batch-testing to guarantee 100% Content Uniformity across every 0.25mg and 0.5mg tablet, providing psychiatrists with a structurally flawless, highly predictable clinical tool.
Therapeutic Indications (Human Use)
Indicated for the targeted, short-term management of severe anxiety and sleep disorders:
- Panic Disorder: Rapid termination of acute panic attacks and severe episodic anxiety.
- Generalized Anxiety Disorder (GAD): Short-term management of severe, debilitating baseline anxiety, tension, and somatic complaints.
- Insomnia: Short-term treatment of sleep onset insomnia (difficulty falling asleep) driven by racing thoughts and severe stress.
Dosage & Administration
Recommended Dosage (Strictly as per Psychiatrist Guidelines):
- Anxiety: Typically 0.25 mg to 0.5 mg taken twice daily.
- Panic Attacks / Insomnia: Typically 0.5 mg to 1.0 mg taken acutely or right before bedtime.
- Maximum Duration: Therapy should not exceed 2 to 4 weeks, including the tapering-off period, to prevent physical dependence.
Safety Warnings (CRITICAL Regulatory & Clinical Data):
- Fatal Respiratory Depression (Opioid Interaction): Co-administration of Etizolam with Opioids (like Tramadol or Codeine) or other CNS depressants causes profound, potentially fatal respiratory depression, coma, and death.
- Tolerance, Dependence, & Withdrawal: Prolonged use leads to severe physical and psychological dependence. Abrupt discontinuation can trigger terrifying withdrawal symptoms, including rebound anxiety, tachycardia, and continuous, life-threatening seizures (Status Epilepticus). The drug MUST be tapered slowly.
- Anterograde Amnesia: Like all drugs in this class, Etizolam can cause the patient to experience total memory loss of events that occur while the drug is active in their system.
- Severe Somnolence: Patients must be explicitly warned not to drive or operate heavy machinery after taking this medication.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Psychiatric Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Anxiolytics, Hypnotics, and Rapid-Burst MD Formulations. Whether you are looking for a reliable Government Tender Supplier for mental health clinics in Southeast Asia or a B2B Pharma Marketplace partner for Latin America, our highly regulated logistics network ensures timely, fully compliant delivery of WHO-GMP certified products.