Description

Ampicillin & Dicloxacillin Capsules

Healthy Inc is a specialized global supplier and exporter of advanced, synergistic beta-lactam antimicrobials. We provide high-purity Ampicillin (250 mg) & Dicloxacillin (250 mg) Capsules, manufactured in WHO–GMP certified, completely dedicated penicillin oral solid dosage facilities. This “Broad-Spectrum & Beta-Lactamase Resistant” combination is a massive-volume, high-priority export to surgical centers, primary care clinics, and government health ministries in LATAM, Southeast Asia, and Africa, serving as the gold-standard empirical intervention for mixed respiratory, dermatological, and post-operative infections.

Product Overview

This formulation contains two highly complementary penicillins: Ampicillin (an extended-spectrum aminopenicillin) and Dicloxacillin (a narrow-spectrum, highly beta-lactamase-resistant isoxazolyl penicillin).

The “Dual-Action Synergistic” Specialist:

• Mechanism 1 (Ampicillin – Broad Coverage): Ampicillin easily penetrates the outer membrane of Gram-negative bacteria via porin channels, binding to Penicillin-Binding Proteins (PBPs) to halt cell wall synthesis. It provides excellent coverage against Streptococcus, Enterococcus, Haemophilus influenzae, and E. coli. However, it is highly susceptible to destruction by beta-lactamase enzymes.
• Mechanism 2 (Dicloxacillin – The Staph Shield): Dicloxacillin features a bulky side chain that sterically hinders beta-lactamase enzymes from breaking its beta-lactam ring. It aggressively targets and destroys penicillinase-producing Staphylococcus aureus (MSSA), which would otherwise survive and neutralize the Ampicillin. Dicloxacillin is noted for having particularly excellent oral absorption among the anti-staphylococcal penicillins.
• The Empirical Advantage: In severe skin infections, wound infections, or respiratory exacerbations, it is often unclear if the pathogen is a Strep, a Gram-negative rod, or a Staph. This 500 mg FDC provides immediate, comprehensive empirical coverage against all three major threats simultaneously, halting tissue destruction while awaiting laboratory cultures.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in specialized moisture-resistant Alu-Alu or heavy-gauge Alu-PVC blister strips to preserve the highly hygroscopic Dicloxacillin salt.

*Pack Sizes: 10×10 Alu-Alu Blisters or 10×10 heavy-gauge Alu-PVC Blisters (Crucial for tropical export climates).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Hospital Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• 100% Dedicated Penicillin Isolation: Regulatory guidelines strictly mandate that penicillins be manufactured in completely isolated facilities to prevent fatal cross-contamination with other drug classes. Our combination capsules are processed in a segregated block with dedicated HVAC and air-filtration systems.
• Hygroscopic Environmental Control: Because Dicloxacillin Sodium degrades in the presence of humidity, our encapsulation lines are rigorously controlled at Relative Humidity (RH) levels below 30%, guaranteeing absolute API stability and full therapeutic potency through the expiry date.

Therapeutic Indications (Human Use)

Indicated for the empirical treatment of severe, mixed bacterial infections:

• Skin and Soft Tissue Infections (SSTIs): Cellulitis, severe boils, abscesses, carbuncles, and infected surgical wounds where both Staph and Strep are suspected.
• Respiratory Tract Infections (RTIs): Bronchopneumonia, acute exacerbations of chronic bronchitis, and severe otitis media.
• Post-Operative Prophylaxis: Administered to prevent mixed infections following orthopedic or general surgery.
• Bone and Joint Infections: Osteomyelitis caused by susceptible organisms.

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Administration (TIMING): Capsules MUST be taken on an empty stomach (at least 30 minutes before or 2 hours after meals). Food heavily impairs the absorption of both Ampicillin and Dicloxacillin, severely reducing peak blood concentrations.
• Standard Adult Dose: One capsule (250mg/250mg) every 6 hours (four times daily).
• Severe Infections: Dosing frequency or capsule volume may be increased under strict medical supervision depending on the severity of the infection.

Safety Warnings (CRITICAL):

• BLACK BOX WARNING (Anaphylaxis): Serious and fatal hypersensitivity reactions occur in patients allergic to penicillins. Strictly contraindicated in patients with a history of penicillin or cephalosporin allergy.
• Gastrointestinal Disruption: Dicloxacillin is known to cause gastrointestinal upset, including nausea, vomiting, and diarrhea. If severe, persistent diarrhea occurs, Clostridioides difficile-associated colitis (CDAC) must be ruled out.
• The “Mononucleosis Rash”: Administering Ampicillin to patients with infectious mononucleosis (Epstein-Barr virus) causes a severe, generalized maculopapular rash. It should not be used if viral mononucleosis is suspected.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Dedicated Penicillin Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in LATAM or a B2B Pharma Marketplace partner for Africa, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.