Description

Calcium Dobesilate Capsules

Healthy Inc is a specialized global supplier and exporter of advanced microvascular and venotonic therapeutics. We provide high-purity Calcium Dobesilate Capsules (500 mg), manufactured in WHO–GMP certified oral solid dosage facilities. This “Endothelial Protector & Venotonic” is a high-volume, multi-specialty export to diabetic eye centers, proctology clinics, phlebology departments, and government health ministries in Africa, LATAM, and Southeast Asia, serving as a highly effective intervention for diabetic retinopathy, severe hemorrhoids, and Chronic Venous Insufficiency (CVI).

Product Overview

This formulation contains Calcium Dobesilate (as Calcium Dobesilate Monohydrate), a synthetic vasoprotective and rheological agent.

The “Microvascular Integrity” Specialist:

• Mechanism 1 (Capillary Permeability & VEGF Modulation): Calcium Dobesilate restores impaired capillary structure. It actively modulates the action of Vascular Endothelial Growth Factor (VEGF) and downregulates the synthesis of pro-inflammatory prostaglandins. This profoundly decreases capillary hyperpermeability and fragility, which is the primary driver of fluid leakage in diabetic retinopathy and macular edema.
• Mechanism 2 (Rheological Improvement): It significantly decreases blood viscosity and plasma hyperviscosity. By inhibiting spontaneous platelet aggregation and improving erythrocyte (red blood cell) flexibility, it drastically improves microcirculation in congested tissues, particularly in the lower extremities.
• Mechanism 3 (Lymphatic Drainage): It actively enhances lymphatic drainage, making it a highly effective, non-surgical pharmacological treatment for reducing the severe edema and pain associated with acute hemorrhoidal attacks and varicose veins.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in moisture-resistant Alu-Alu or Alu-PVC blister strips.

*Pack Sizes: 10×10 Alu-PVC Blisters or Alu-Alu Blisters. (Alu-Alu recommended to prevent moisture degradation of the highly soluble salt).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Multi-Specialty Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Hygroscopic Salt Stabilization: Calcium Dobesilate is extremely water-soluble and hygroscopic. Our manufacturing processes utilize strict climate-controlled environments (RH <40%) during encapsulation to prevent the active ingredient from absorbing atmospheric moisture, ensuring the powder remains free-flowing and the capsule shell does not degrade during its 24-month shelf life.
• Rapid Gastric Absorption: Formulated with premium disintegrants to ensure the capsule releases its contents rapidly in the stomach, allowing the drug to achieve peak plasma concentrations within 3 to 6 hours.

Therapeutic Indications (Human Use)

Indicated for the management of severe microvascular and venous disorders:

• Diabetic Microangiopathy: Treatment of diabetic retinopathy to prevent capillary leakage and delay the progression of visual loss.
• Chronic Venous Insufficiency (CVI): Relief of pain, cramps, paresthesia, and severe lower-limb edema associated with varicose veins and deep vein thrombosis post-phlebitic syndrome.
• Hemorrhoidal Disease: Acute and maintenance treatment of internal and external hemorrhoids, rapidly reducing bleeding, pain, and inflammation.

Dosage & Administration

Recommended Dosage (Strictly as per Physician/Specialist):

• Administration (CRITICAL FOOD RULE): Must be taken orally, DURING or immediately after meals to minimize gastrointestinal discomfort.
• Diabetic Retinopathy: Typically 500 mg (1 capsule) one to two times daily for several months, depending on severity and ophthalmological evaluation.
• Chronic Venous Insufficiency & Hemorrhoids: Typically 500 mg (1 capsule) once or twice daily for 2 to 3 weeks, after which the dose may be reduced to a maintenance level of 500 mg once daily.

Safety Warnings (CRITICAL):

• Agranulocytosis Risk: In very rare cases, Calcium Dobesilate has been associated with severe agranulocytosis (a dangerous drop in white blood cells). Patients must be instructed to immediately stop the drug and seek emergency care if they develop a sudden high fever, severe sore throat, or oral mucosal infections.
• Severe Renal Impairment: The drug is primarily excreted by the kidneys. The dosage must be drastically reduced or avoided in patients with severe renal failure, particularly those requiring dialysis.
• Gastrointestinal Intolerance: May cause mild to moderate nausea or diarrhea, which is usually resolved by ensuring the capsule is taken with a heavy meal or reducing the dose.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Vascular and Venotonic Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.