Description

Piperacillin & Tazobactam Injection (4.5 g)

Healthy Inc is a specialized global supplier and exporter of advanced penicillin combinations. We provide high-purity Piperacillin & Tazobactam Injection (4.5 g / 2.25 g), manufactured in dedicated WHO–GMP certified sterile penicillin facilities. This “ICU Workhorse” is a mandatory export to critical care units, burn centers, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the definitive empiric therapy for severe nosocomial infections, particularly those caused by Pseudomonas aeruginosa.

Product Overview

This formulation combines Piperacillin, an extended-spectrum ureidopenicillin, with Tazobactam, a suicide beta-lactamase inhibitor.

The “Antipseudomonal” Specialist:

• Mechanism (The Synergy):
  • Piperacillin: Binds to Penicillin-Binding Proteins (PBPs) inside the bacterial cell wall, inhibiting septum formation and causing cell lysis. It is specifically designed to target Gram-negative bacteria like Pseudomonas.
  • Tazobactam: Acts as a “decoy,” irreversibly binding to and neutralizing beta-lactamase enzymes (including plasmid-mediated enzymes) produced by resistant bacteria. This protects Piperacillin from destruction, restoring its potency.
• Broad Spectrum: Covers Gram-positives (Staph/Strep), Gram-negatives (E. coli, Klebsiella), and Anaerobes (Bacteroides), making it ideal for “mixed” intra-abdominal infections.
• Time-Dependent Killing: Efficacy depends on the time the drug concentration remains above the Minimum Inhibitory Concentration (T > MIC). Extended infusions (over 3-4 hours) maximize this effect.

Product Composition & Strength

We supply this product as a Sterile Lyophilized Powder buffered with Sodium Citrate/EDTA.

*Pack Sizes: Single Vial or Tray of 10 Vials.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Cross-Contamination Control: Penicillins are highly allergenic. Our facility operates a strictly segregated “Penicillin Block” with dedicated HVAC systems and personnel to ensure zero cross-contamination with other antibiotics like Cephalosporins or Carbapenems.
• Cold Chain Stability: While the powder is stable at room temperature, our lyophilization cycle ensures a robust cake structure that dissolves rapidly (< 3 minutes) without foaming, crucial for busy ICU settings.

Therapeutic Indications (Human Use)

Indicated for the treatment of moderate to severe polymicrobial infections:

• Nosocomial Pneumonia: Hospital-acquired and Ventilator-associated pneumonia (VAP).
• Intra-abdominal Infections: Appendicitis, Peritonitis (often used with Amikacin).
• Skin and Skin Structure Infections: Cellulitis, Diabetic Foot Infections.
• Gynecological Infections: Postpartum endometritis, Pelvic Inflammatory Disease (PID).
• Febrile Neutropenia: Empiric therapy in cancer patients.

Dosage & Administration

Recommended Dosage (Strictly as per Critical Care Specialist):

• Route: Intravenous (IV) Infusion ONLY. (Not for IM use).
• Standard Adult Dose: 4.5 g every 6 to 8 hours.
• Nosocomial Pneumonia: 4.5 g every 6 hours (Total 18 g daily).
• Extended Infusion Protocol: Administering each dose over 3 to 4 hours significantly improves outcomes against resistant Pseudomonas.
• Renal Adjustment: Dose reduction is mandatory if Creatinine Clearance (CrCl) is < 40 ml/min to prevent neurotoxicity (seizures).

Safety Warnings (CRITICAL):

• Anaphylaxis: FATAL RISK. Contraindicated in patients with a history of severe allergic reactions to Penicillins, Cephalosporins, or Carbapenems.
• Sodium Load: Each 4.5g vial contains significant sodium. Use caution in patients with Congestive Heart Failure (CHF).
• Bleeding Risk: High doses may impair platelet aggregation. Monitor coagulation parameters.
• Compatibility: Physically Incompatible with Aminoglycosides (e.g., Gentamicin). Do not mix in the same syringe or IV bag.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Beta-Lactams, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.