In the pharmaceutical industry, Isosorbide Mononitrate 10 mg is a standard-strength organic nitrate vasodilator. As a pharmacist and manufacturer, I characterize the 10 mg tablet as a critical “starting dose.” Because nitrates can cause significant initial headaches (due to rapid vasodilation), this lower strength is used to titrate the patient upward, allowing their vascular system to adapt before moving to the 20 mg or 40 mg maintenance doses.
Primary Clinical Uses
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Prophylaxis of Angina Pectoris: Its primary role is the long-term prevention of chest pain caused by coronary artery disease.
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Chronic Heart Failure: Used as an adjunctive treatment to reduce the workload on the heart, often in combination with other cardiovascular medications.
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Maintenance Therapy: Unlike nitroglycerin, which is for acute attacks, the 10 mg mononitrate is taken on a regular schedule to provide a consistent “nitrate-rich” environment in the bloodstream.
Mechanism of Action: Vascular Relaxation
Isosorbide Mononitrate is the active metabolite of Isosorbide Dinitrate. It works by relaxing the smooth muscles of the blood vessels.
Nitric Oxide (NO) Release: The drug acts as a donor of nitric oxide.
cGMP Activation: NO stimulates the enzyme guanylate cyclase, increasing levels of cyclic guanosine monophosphate (cGMP).
Dilation: This biochemical cascade triggers the relaxation of veins and, to a lesser extent, arteries.
Preload Reduction: By dilating the veins, it reduces the volume of blood returning to the heart (preload), lowering the oxygen demand of the heart muscle and preventing the onset of angina.
The Manufacturer’s Perspective: Formulation & Export
From a production and global trade standpoint, Isosorbide Mononitrate 10 mg is a high-demand cardiovascular staple:
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Avoidance of Nitrate Tolerance: As a pharmacist, you know that 24-hour nitrate exposure leads to “tolerance” (the drug stops working). As a manufacturer, we provide clinical dosing guidelines (the “asymmetric dosing” schedule) to ensure a 7-8 hour nitrate-free interval each day.
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API Purity & Stability: We strictly follow BP/USP/IP monographs. Because nitrates are moisture-sensitive, we utilize Alu-Alu blister packaging to ensure a 36-month shelf life for export to Zone IVb regions (Africa, Southeast Asia).
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B2B & Institutional Supply: This is a core product for cardiovascular clinics and government health tenders. Our Mumbai-based facility provides full CTD/eCTD Dossiers to support international registration against the innovator (Monoket or Ismo).