In the pharmaceutical industry, Ciprofloxacin 100 mg is a second-generation fluoroquinolone antibiotic. As a pharmacist, I view this specific low-strength dosage as a targeted therapeutic tool, primarily utilized in pediatric care or for very specific, uncomplicated adult infections where higher doses (250 mg or 500 mg) are not clinically necessary.
Primary Clinical Uses
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Uncomplicated Urinary Tract Infections (UTIs): Frequently used for short-course treatment of acute, uncomplicated cystitis in women.
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Pediatric Applications: Used to treat complicated UTIs and pyelonephritis in children (ages 1-17), where the dosage is strictly weight-based.
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Post-Exposure Inhalation Anthrax: Part of the prophylactic regimen for children and adults following exposure to Bacillus anthracis.
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Cystic Fibrosis: Management of pulmonary exacerbations caused by Pseudomonas aeruginosa in pediatric patients.
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Gonorrhea: Though resistance has limited its use, it was historically used as a single 100 mg dose for uncomplicated urethral and endocervical infections.
Mechanism of Action
Ciprofloxacin is a rapidly bactericidal agent. It works by inhibiting two essential bacterial enzymes: DNA Gyrase (Topoisomerase II) and Topoisomerase IV.
By targeting these enzymes, Ciprofloxacin prevents the bacteria from “unzipping” and repairing their DNA during replication. This leads to irreversible DNA damage and rapid bacterial cell death. Its broad-spectrum activity is particularly effective against Gram-negative pathogens like E. coli and Pseudomonas.
The Manufacturer’s Perspective: Formulation & Export
From a manufacturing and global trade standpoint, Ciprofloxacin 100 mg requires precise quality controls:
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API Purity: As a WHO-GMP manufacturer, we ensure the Ciprofloxacin Hydrochloride API meets strict BP/USP/IP standards, specifically monitoring for the “Ethylenediamine” impurity.
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Taste Masking: Ciprofloxacin is extremely bitter. We utilize advanced film-coating technology to ensure the 100 mg tablet is palatable, especially given its frequent use in adolescent and pediatric populations.
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Stability for Global Trade: Ciprofloxacin is light-sensitive. We utilize Alu-Alu or opaque PVC/PVDC blister packaging to maintain its 36-month shelf life during export to hot and humid Zone IVb regions (Africa and Southeast Asia).
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B2B & Tender Supply: This strength is a staple for pediatric hospital tenders and international NGOs. Our Mumbai facility provides full CTD/eCTD Dossiers to support rapid registration for our B2B partners.