In the pharmaceutical industry, Aceclofenac tablets (commonly 100 mg and 200 mg SR) are highly effective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) of the phenylacetic acid class. As a pharmacist, I recognize Aceclofenac for its superior tolerability profile and its targeted ability to inhibit the mediators of pain and inflammation.
Primary Clinical Uses
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Osteoarthritis (OA): Effectively manages joint pain and stiffness by reducing inflammation in the synovial fluid.
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Rheumatoid Arthritis (RA): Provides systemic relief from chronic inflammation and prevents morning stiffness in patients with autoimmune joint conditions.
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Ankylosing Spondylitis: A primary choice for reducing spinal pain and improving mobility in patients with this chronic inflammatory condition.
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Acute Musculoskeletal Pain: Widely used for the short-term relief of pain associated with trauma, lower back pain, and dental procedures.
Mechanism of Action
Aceclofenac acts as a potent inhibitor of the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins—the mediators of pain, swelling, and inflammation. Unlike many other NSAIDs, Aceclofenac also inhibits the synthesis of inflammatory cytokines like IL-1β and TNF, and stimulates the synthesis of cartilage matrix, potentially offering a chondroprotective (cartilage-protecting) effect.
The Manufacturer’s Perspective: Formulation & Export
From a manufacturing and global trade standpoint, Aceclofenac presents specific opportunities for high-standard WHO-GMP production:
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Sustained Release (SR) Technology: Formulating the 200 mg SR version involves advanced polymer matrix systems to ensure a steady release of the drug over 24 hours, significantly improving patient compliance.
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Stability in Extreme Climates: Our formulations are validated for Zone IVb (Hot/Humid) conditions, ensuring the tablets remain stable and effective during export to markets in Africa, LATAM, and Southeast Asia.
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Regulatory Readiness: As an export-oriented firm, we provide comprehensive documentation, including CTD/eCTD Dossiers, to facilitate smooth registration for our international B2B partners.
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Logistics Hub: Operating from Mumbai allows us to specialize in mixed-container consolidation, offering a streamlined supply chain for diverse pharmaceutical portfolios.