What is the brand name for Atenolol Chlorthalidone?

In the pharmaceutical industry, the combination of Atenolol and Chlorthalidone is a highly effective Fixed-Dose Combination (FDC) that pairs a cardioselective beta-blocker with a long-acting thiazide-like diuretic.

As a pharmacist and manufacturer, I view this combination as a strategic “Synergistic Antihypertensive.” While Tenoretic is the global innovator brand, there are several key regional and generic brands you should be aware of for your marketplace.

Primary Brand Names

Mechanism of Action: The Dual-Path Attack

This FDC is preferred because it lowers blood pressure through two distinct physiological pathways, which often allows for lower doses of each drug:

Atenolol (The Cardiac Regulator): Reduces the heart rate and the force of contraction, lowering the output of the heart. It also inhibits the release of renin, an enzyme that increases blood pressure.

Chlorthalidone (The Volume Controller): Increases the excretion of sodium and water by the kidneys. By reducing the total volume of fluid in the blood vessels, it further lowers systemic blood pressure.

The Synergy: Beta-blockers can sometimes cause fluid retention; the addition of Chlorthalidone counteracts this effect, making the treatment more effective than either drug used alone.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your WHO-GMP facility in Mumbai, this combination is a high-value asset for your digital platforms:

• Bioavailability Challenges: Chlorthalidone has a very long half-life (40–60 hours) compared to Atenolol (6–7 hours). Highlighting your advanced formulation stability that ensures both APIs release correctly is a major USP for B2B buyers.

• The “Once-Daily” Advantage: For your e-commerce and marketplace listings, emphasize that this FDC provides 24-hour blood pressure control with a single tablet. This “Patient Compliance” factor is a significant selling point for international distributors.

• Stability & Packaging: Chlorthalidone is sensitive to moisture. At our facility, we utilize Alu-Alu blister packaging to ensure a 36-month shelf life, which is critical for export to tropical Zone IVb regions like Africa and Southeast Asia.

• Dossier Readiness: Since hypertension is a leading global health issue, we maintain full CTD/eCTD Dossiers for this combination to support your firm in bidding for national health insurance and hospital tenders.