In the pharmaceutical industry, Dicyclomine Hydrochloride 10 mg is a synthetic tertiary amine with selective anticholinergic and antispasmodic properties. As a pharmacist and manufacturer, I view this SKU as a “Smooth Muscle Relaxant”—it is the first-line therapy for functional bowel disorders where hypermotility and cramping are the primary symptoms.

At your WHO-GMP facility in Mumbai, where you likely produce the 10 mg and 20 mg tablets or syrups, understanding the “Muscarinic Blockade” is a vital technical value-add for your gastroenterology portfolio.

Primary Clinical Indications

Dicyclomine 10 mg is specifically indicated for the management of gastrointestinal motility disorders:

• Irritable Bowel Syndrome (IBS): It is the primary treatment for the “cramping” and abdominal pain associated with IBS.

• Functional Bowel Disorders: Used to treat general intestinal hypermotility (overactive gut) and spasms.

• Colic Relief: In liquid form, low doses are sometimes used for infant colic, though this requires extreme caution and specific pediatric oversight.

Mechanism: Dual-Action Antispasmodic

Dicyclomine works by “quieting” the involuntary muscles of the digestive tract:

Anticholinergic Effect: It acts as a competitive antagonist at Muscarinic ($M_1$ and $M_3$) receptors. By blocking the neurotransmitter Acetylcholine, it prevents the signals that cause the gut muscles to contract.

Direct Spasmolytic Effect: At higher concentrations, it has a direct relaxing effect on the smooth muscle fibers themselves, independent of the nervous system.

Result: This dual action reduces the “spasm” (cramp) and slows down the transit time of food through the gut, relieving pain and urgency.

The Pharmacist’s “Technical Warning”

• Anticholinergic Side Effects: Patients may experience the classic “dry” symptoms: dry mouth, blurred vision, dizziness, and constipation.

• Glaucoma Alert: It is strictly contraindicated in patients with Narrow-Angle Glaucoma, as it can dangerously increase intraocular pressure.

• Heat Stroke Risk: Because it reduces sweating (anhidrosis), patients in hot climates like Mumbai or Africa must be warned about the risk of overheating during physical activity.

• The “Before Meals” Rule: For maximum efficacy in IBS, the 10 mg dose should be taken 30 to 60 minutes before a meal to preemptively block meal-induced spasms.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai:

• The “Syrup vs. Tablet” Strategy: On your digital marketplace, highlight your Dicyclomine 10mg/5ml Syrup. This is a high-demand SKU for geriatric and pediatric B2B clients who require precise dose titration.

• Stability for Export: Dicyclomine is stable but sensitive to light. For export to Zone IVb tropical regions, utilizing amber-colored bottles for liquid and opaque PVC/PVDC or Alu-Alu blisters for tablets is essential for a 36-month shelf life.

• Dossier Support: We provide full WHO-standard CTD/eCTD Dossiers to support your firm’s registration in international gastrointestinal and maternal-child health tenders.