Healthy Inc > Blog > Paracetamol Phenylephrine CPM Caffeine tablets
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What is Paracetamol phenylephrine HCL CPM and caffeine tablets used for?

In the pharmaceutical industry, the combination of Paracetamol, Phenylephrine HCl, Chlorpheniramine Maleate (CPM), and Caffeine is known as a Complete Cold, Flu, and Antiallergic formulation.

As a pharmacist and manufacturer, I classify this as a “Total Symptom Management” tablet. While the previous formula we discussed was for daytime use, the addition of CPM makes this version more potent for patients experiencing significant allergic symptoms like sneezing and watery eyes.

Primary Clinical Uses

  • Advanced Cold & Flu Relief: Treatment of fever, headache, and severe body aches.

  • Allergic Rhinitis: Specifically effective for “wet” symptoms—constant sneezing, runny nose, and itchy throat.

  • Sinusitis: Relieves sinus pressure and the accompanying “heavy-head” feeling.

  • Vasomotor Rhinitis: Management of non-allergic nasal congestion.

Quadruple Mechanism of Action

Ingredient Class Action
Paracetamol Analgesic Reduces fever and blocks pain signals in the CNS.
Phenylephrine HCl Decongestant Shrinks swollen nasal membranes to open airways.
CPM Antihistamine Blocks $H_1$ receptors to stop sneezing and runny nose.
Caffeine Adjuvant Accelerates paracetamol absorption and reduces CPM-induced drowsiness.

The Pharmacist’s Insight: The inclusion of CPM (an H1 antagonist) can cause sedation. However, the Caffeine acts as a pharmacological “balancer,” helping the patient remain alert enough for daily activities while the antihistamine works on the allergy.

The Manufacturer’s Perspective: Technical & Export

Producing this 4-in-1 FDC in a WHO-GMP facility like yours in Mumbai involves high-level formulation expertise:

  • Synergistic Formulation: A common export ratio is Paracetamol 500mg + Phenylephrine 5mg + CPM 2mg + Caffeine 30mg.

  • Coating for Stability: Since both Phenylephrine and CPM can be sensitive to environmental factors, we utilize Film-Coating. This not only protects the APIs but also masks the bitter taste of caffeine and paracetamol, increasing consumer preference.

  • Packaging for Tropical Zones: To ensure a 36-month shelf life in Zone IVb (Africa/SE Asia), we recommend Alu-Alu or high-grade PVDC blisters. This prevents moisture-induced degradation of the phenylephrine.

  • B2B Strategy: This is a “Value-Added” product. On your digital platforms, you can market this as a superior alternative to basic paracetamol, offering higher profit margins for your international distributors.

Paracetamol Caffeine Phenylephrine Hcl cpm

Posted on:

What is Paracetamol phenylephrine HCL CPM and caffeine tablets used for?

In the pharmaceutical industry, the combination of Paracetamol, Phenylephrine HCl, Chlorpheniramine Maleate (CPM), and Caffeine is considered a Total Multi-Symptom Relief formulation.

As a pharmacist and manufacturer, I classify this as a “Complete Cold & Flu” treatment. Unlike the “Daytime” versions, the addition of CPM makes this an all-in-one solution that addresses the “wet” symptoms of a cold (runny nose and sneezing) in addition to pain, congestion, and lethargy.

Primary Clinical Uses

  • Common Cold & Influenza: Comprehensive relief from fever, shivering, and body aches.

  • Allergic Rhinitis: Specifically effective when allergies cause both congestion and a runny nose.

  • Sinusitis: Reduces sinus pressure while drying up excessive mucus.

  • Hay Fever: Relieves itchy/watery eyes, sneezing, and nasal blockage.

Quadruple Mechanism of Action (The 4-Way Attack)

Paracetamol (500 mg):

Action: Analgesic and Antipyretic.

Result: Blocks pain signals in the CNS and resets the hypothalamic heat-regulating center to reduce fever.

Phenylephrine HCl (5 mg – 10 mg):

Action: Decongestant ($\alpha_1$-adrenergic agonist).

Result: Constricts dilated blood vessels in the nasal mucosa, reducing swelling and opening the airways.

Chlorpheniramine Maleate (CPM) (2 mg – 4 mg):

Action: First-generation Antihistamine ($H_1$ receptor antagonist).

Result: Blocks the action of histamine, which stops sneezing, itching, and “dries up” a runny nose (rhinorrhea).

Caffeine (30 mg):

    • Action: Analgesic Adjuvant & Mild Stimulant.

    • Result: Accelerates the absorption of Paracetamol and helps counteract the drowsiness often caused by the CPM.

The Manufacturer’s Perspective: Formulation & Export

From a production standpoint at your WHO-GMP facility in Mumbai, this formulation presents specific technical opportunities for your firm:

  • The Stability of CPM: Chlorpheniramine is relatively stable, but the overall blend must be protected from moisture to prevent the Phenylephrine from degrading. We utilize Alu-Alu or high-barrier PVC/PVDC blister packaging to ensure a 36-month shelf life for export to Zone IVb regions.

  • Balancing the “Drowsiness” Factor: Although Caffeine is included to keep the patient alert, the CPM still has a sedative effect. As a firm owner, your Product Information Leaflet (PIL) should include a “Caution: May cause drowsiness” warning, which is a regulatory requirement for export to most Western and African markets.

  • Market Positioning: On your digital and social media platforms, you can market this as a “Professional Strength” cold formula. It is highly sought after in B2B trading because it replaces the need for patients to buy three separate medicines.

  • Dossier Availability: Our Mumbai facility provides full CTD/eCTD Dossiers to support international registration and supply to hospital and retail pharmacy chains.

Paracetamol Caffeine Phenylephrine Hcl cpm

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