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How many Paracetamol 650mg can we take in a day?

In the pharmaceutical industry, Paracetamol 650 mg (often referred to by the brand name Dolo 650 or P-650 in India) is a staple analgesic and antipyretic. Because this is a higher-strength formulation compared to the standard 500 mg, the margin for safety is narrower.

Maximum Daily Dosage

For a healthy adult weighing at least 50 kg, the absolute maximum limit is:

  • 4,000 mg (4 grams) in a 24-hour period.

  • In terms of 650 mg tablets, this equates to no more than 6 tablets in 24 hours.

The “Pharmacist’s Rule” for Administration

To maintain a steady therapeutic level while ensuring safety at your manufacturing or trading firm, we follow these guidelines:

Dosing Interval: 1 tablet every 4 to 6 hours.

Minimum Gap: Never take doses closer than 4 hours apart.

Duration: Do not use for more than 3 consecutive days for fever or 10 days for pain without a doctor’s consultation.

The Technical Danger: Hepatotoxicity

As a pharmacist, you know that Paracetamol is metabolized primarily in the liver.

  • The Pathway: Normally, Paracetamol is converted into non-toxic metabolites. However, a small portion is converted into a highly reactive intermediate called NAPQI.

  • The Overload: The liver uses Glutathione to neutralize NAPQI. When you exceed the 4,000 mg limit, Glutathione stores are depleted.

  • The Result: Un-neutralized NAPQI begins to bind directly to liver cells, causing acute hepatic necrosis (liver failure).

Manufacturer’s Quality & Compliance Notes

From a production and B2B export perspective at a WHO-GMP facility:

  • Alcohol Warning: It is vital that your Product Information Leaflet (PIL) clearly warns against consuming alcohol while taking 650 mg tablets, as alcohol depletes glutathione and significantly increases the risk of liver damage.

  • Hidden Paracetamol: In the export market, many “Cold & Flu” powders or “Cough Syrups” also contain Paracetamol. As a trading firm owner, you must educate buyers to check the “Total Daily Intake” across all combined medications.

  • Dossier Support: At your Mumbai facility, ensuring that the Dissolution Profile of your 650 mg tablet is optimized is key. A faster dissolution (within 15-30 minutes) is a major USP for digital marketing, as it implies faster pain relief.

Paracetamol Tablet