Healthy Inc > Blog > Ibuprofen 400mg manufacturer India
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Is ibuprofen a painkiller?

In the pharmaceutical industry, Ibuprofen is a standard-bearer of the Non-Steroidal Anti-Inflammatory Drug (NSAID) class. As a pharmacist and manufacturer, I can confirm that it is indeed a potent painkiller (analgesic), but its unique value lies in its triple-action profile: it treats pain, reduces inflammation, and lowers fever (antipyretic).

At your WHO-GMP facility in Mumbai, where you likely produce 200 mg, 400 mg, and 600 mg tablets, understanding the “COX-Inhibition” mechanism is the technical foundation for your entire analgesic portfolio.

The Triple-Action Profile

Ibuprofen is “more” than just a painkiller; it is categorized by its three primary clinical effects:

Effect Technical Rationale
Analgesic (Pain) Relieves mild to moderate pain (headache, dental pain, dysmenorrhea) by blocking pain signals.
Anti-inflammatory Reduces swelling and redness at the site of injury (e.g., arthritis, sprains).
Antipyretic (Fever) Resets the body’s “thermostat” in the hypothalamus to reduce high body temperatures.

Mechanism: The COX-1 and COX-2 Blockade

Ibuprofen works by shutting down the production of Prostaglandins, which are the chemicals that trigger pain and inflammation:

Enzyme Inhibition: It non-selectively inhibits Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2).

Prostaglandin Suppression: By blocking these enzymes, the body stops converting arachidonic acid into prostaglandins.

The Safety Trade-off: While blocking COX-2 stops pain, blocking COX-1 also removes the protective mucus layer of the stomach, which is why Ibuprofen can cause gastric irritation.

The Pharmacist’s “Technical Warning”

  • The “With Food” Rule: Ibuprofen should always be taken with a full meal or milk to protect the gastric mucosa from direct irritation.

  • The “Aspirin” Conflict: If a patient takes low-dose Aspirin for heart health, Ibuprofen can interfere with Aspirin’s anti-platelet effect. Advise taking Ibuprofen 8 hours before or 30 minutes after Aspirin.

  • Renal Loading: Ibuprofen reduces blood flow to the kidneys. Use with extreme caution in patients with existing renal impairment or dehydration.

  • Asthma Alert: About 10% of asthmatics may experience a “flare” or bronchospasm when taking NSAIDs like Ibuprofen.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai:

  • The “Softgel” USP: On your digital marketplace, emphasize the Bioavailability of your Softgel formulations. Softgels typically reach peak plasma levels ($T_{max}$) faster than compressed tablets, offering quicker pain relief.

  • Stability for Export: Ibuprofen is relatively stable but sensitive to high humidity. Utilizing PVDC-coated PVC or Alu-Alu blisters is the industry standard for ensuring a 36-month shelf life in Zone IVb tropical regions.

  • Dossier Support: We provide full WHO-standard CTD/eCTD Dossiers to support your firm’s registration in international tenders for pain management and primary care.

Ibuprofen Tablets

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Is ibuprofen 400 good for pain?

In the pharmaceutical industry, Ibuprofen 400 mg is considered the “Standard Therapeutic Dose” for moderate pain and inflammation. As a pharmacist and manufacturer, I classify this as a highly effective Non-Steroidal Anti-Inflammatory Drug (NSAID) that is superior to paracetamol for pain accompanied by swelling or redness.

At your WHO-GMP facility in Mumbai, the 400 mg strength is likely your highest-volume Ibuprofen SKU, serving as a versatile product for both over-the-counter (OTC) and prescription markets.

Primary Clinical Efficacy

Ibuprofen 400 mg is “good” and clinically indicated for:

  • Musculoskeletal Pain: Excellent for backaches, sprains, and sports injuries.

  • Dental Pain: Often the first choice for post-procedural dental inflammation.

  • Dysmenorrhea: Highly effective at reducing the prostaglandins that cause menstrual cramping.

  • Headaches & Migraines: Provides rapid relief for tension-type headaches.

  • Arthritic Flare-ups: Manages acute episodes of joint pain and stiffness.

Mechanism: The COX Enzyme Blockade

Ibuprofen targets the underlying cause of pain—inflammation—rather than just masking the signal in the brain.

Inhibition: It inhibits the Cyclooxygenase (COX-1 and COX-2) enzymes.

Prostaglandin Reduction: By blocking these enzymes, it stops the conversion of arachidonic acid into prostaglandins, which are the chemical mediators that sensitize pain receptors and cause swelling.

Antipyretic Effect: It also acts on the hypothalamus to reduce fever.

The Pharmacist’s “Technical Warning”

As you promote your pharmaceutical firm on digital and social platforms, providing these technical insights is essential for professional authority:

  • The “Ceiling Effect”: For simple pain, increasing the dose beyond 400 mg may not provide significantly more relief but will increase the risk of side effects.

  • Gastric Safety: Advise taking the tablet with a full glass of water and after food to minimize the risk of stomach irritation or ulcers.

  • Asthma Caution: Approximately 10% of asthmatics may experience a “bronchospasm” when taking NSAIDs.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai:

  • The “Universal Analgesic” USP: On your marketplace, highlight that your Ibuprofen 400 mg meets BP/USP/IP standards, ensuring rapid dissolution and predictable bioavailability—critical for international B2B buyers.

  • Packaging Strategy: For tropical export (Zone IVb), we utilize Alu-Alu or PVDC-coated PVC blisters to prevent the tablets from becoming brittle or discolored due to humidity.

  • FDC Opportunity: Consider promoting an Ibuprofen 400 mg + Paracetamol 325 mg combination. This “Dual-Action” formula is a high-growth segment in the global pain-management market.

    Dossier Support: We provide full CTD/eCTD Dossiers to assist your firm in registering this product in emerging markets.

Ibuprofen Tablets

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