In the pharmaceutical industry, Ofloxacin 200 mg is a broad-spectrum fluoroquinolone antibiotic. As a pharmacist and manufacturer, I can confirm that the standard adult dosage is typically one 200 mg tablet twice a day (every 12 hours). However, the exact frequency and duration are technically dictated by the site and severity of the infection.

At your WHO-GMP facility in Mumbai, where you focus on technical precision and global B2B exports, providing these specific indications is a vital technical value-add for your anti-infective portfolio.

Therapeutic Profile: Dosing by Indication

For an adult with normal renal function, the following 200 mg regimens are standard:

Indication	Frequency (Adults)	Typical Duration
Uncomplicated UTI (Cystitis)	200 mg twice daily	3 – 7 Days
Complicated UTI / Pyelonephritis	200 mg twice daily	10 Days
Prostatitis (E. coli)	300 mg twice daily*	6 Weeks
Lower Respiratory Infections	400 mg twice daily*	7 – 10 Days
Skin/Soft Tissue Infections	400 mg twice daily*	10 Days

> Note: For higher doses (400 mg), two 200 mg tablets are taken together or a single 400 mg tablet is used.

Mechanism: Topoisomerase II & IV Inhibition

Ofloxacin works by physically “unwinding” the bacterial survival mechanism:

Enzyme Binding: It inhibits DNA Gyrase (Topoisomerase II) and Topoisomerase IV.

Supercoiling Blockade: These enzymes are responsible for the supercoiling and uncoiling of bacterial DNA during replication.

Lethal Fragmentation: By blocking these enzymes, Ofloxacin causes the bacterial DNA to become tangled and broken, leading to rapid bacterial cell death (bactericidal action).

The Pharmacist’s “Technical Warning”

• The “Chelation” Rule: As a pharmacist, I must emphasize that Ofloxacin should not be taken within 2 hours of antacids, iron supplements, multivitamins with zinc, or sucralfate. These minerals bind to the drug and prevent its absorption.

• The “Tendon” Alert: Fluoroquinolones carry a global warning for Tendinitis and Tendon Rupture. Patients over 60 or those on corticosteroids are at higher risk. Any sudden joint pain requires immediate cessation.

• Photosensitivity: Advise patients to avoid excessive sunlight or tanning beds, as Ofloxacin makes the skin significantly more prone to severe sunburn.

• Renal Adjustment: In patients with a $CrCl < 50 \text{ mL/min}$, the frequency is typically reduced to once every 24 hours to prevent toxicity.

The Manufacturer’s Perspective: Technical & Export

From a production and B2B standpoint at your facility in Mumbai:

• The “FDC Advantage” USP: On your digital marketplace, highlight your Ofloxacin + Ornidazole combinations. This Fixed-Dose Combination (FDC) is a high-demand SKU in many markets for treating mixed aerobic-anaerobic infections (like GI or pelvic infections).

• Stability for Export: Ofloxacin is stable but light-sensitive. Utilizing opaque PVC/PVDC or Alu-Alu blister packaging is the industry standard for ensuring a 36-month shelf life in Zone IVb tropical regions.

• Dossier Support: We provide full WHO-standard CTD/eCTD Dossiers to support your firm’s registration in international tenders for “Essential Anti-Infective Medicines.”