In the pharmaceutical industry, Trypsin-Chymotrypsin tablets (standardized at 100,000 Armour Units) are a potent proteolytic enzyme combination. As a pharmacist, I view this formulation as a highly effective “biological response modifier” used to accelerate the resolution of inflammatory edema and promote tissue repair following trauma or surgery.

Primary Clinical Uses

• Post-Operative Inflammation: Extensively used after surgical procedures (orthopedic, gynecological, or general surgery) to reduce swelling, hematoma (bruising), and pain at the incision site.

• Traumatic Injuries: Indicated for the management of accidental injuries, such as sprains, strains, fractures, and sports-related soft tissue trauma.

• Chronic Respiratory Conditions: Used as an adjunctive therapy in conditions like bronchitis and sinusitis to thin out thick mucus secretions (mucolytic effect), making them easier to expectorate.

• Pelvic Inflammatory Disease (PID): Often prescribed in gynecology to resolve inflammation and improve the penetration of antibiotics into the affected tissues.

• Tooth Extractions: Frequently used in dentistry to minimize post-extraction swelling and pain.

Mechanism of Action

Trypsin and Chymotrypsin are enzymes that act as anti-inflammatory catalysts. Unlike NSAIDs (which inhibit COX enzymes), these proteolytic enzymes work through the following pathways:

Fibrinolysis: They break down fibrin deposits that form around inflamed areas. These fibrin walls often “wall off” the infection, trapping fluid and preventing antibiotics from reaching the site.

Restoring Microcirculation: By clearing fibrin and cellular debris, these enzymes restore the flow of blood and lymph in the micro-vasculature. This reduces edema (swelling) and allows the body’s natural defense mechanisms to clear the inflammation.

TNF-$\alpha$ Modulation: They help regulate pro-inflammatory cytokines, preventing an excessive or prolonged inflammatory response.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing and global trade standpoint, Trypsin-Chymotrypsin is a technically sensitive biological product:

• Enteric Coating (Crucial): These enzymes are proteins that would be instantly destroyed by stomach acid. As a WHO-GMP manufacturer, we utilize a high-quality enteric coating that ensures the tablet remains intact in the stomach and only dissolves in the $pH$-neutral environment of the small intestine.

• Potency & Standardization: We measure efficacy in Armour Units (or AU). Ensuring that each tablet provides exactly 100,000 units requires precise API handling and environmental controls to prevent enzymatic degradation during the manufacturing process.

• Stability for Export: Enzymes are heat-sensitive. We prioritize Alu-Alu blister packaging to protect the tablets from moisture and temperature fluctuations during transit to Zone IVb regions.

• B2B & Surgical Supply: This is a high-demand item for surgical hospitals and orthopedic clinics. Our Mumbai facility provides the CTD/eCTD Dossiers and stability data required for international registration and hospital tenders.