In the pharmaceutical industry, Levocetirizine Dihydrochloride 5 mg is a highly potent, third-generation non-sedating antihistamine. As a pharmacist and manufacturer, I view Levocetirizine as the refined, active R-enantiomer of Cetirizine. It offers higher affinity for $H_1$ receptors, which allows for a smaller dose (5 mg vs. 10 mg) and a significantly lower risk of drowsiness.

Primary Clinical Uses

• Allergic Rhinitis: Effective for both seasonal (hay fever) and perennial allergies. It relieves symptoms like sneezing, rhinorrhea (runny nose), and nasal congestion.

  Allergic Conjunctivitis: Reduces red, itchy, and watery eyes caused by environmental allergens like pollen, dust mites, or pet dander.

• Chronic Idiopathic Urticaria: The primary treatment for long-term hives and skin itching, providing relief from wheals and redness.

• Allergic Dermatitis: Used to manage itching associated with eczema or insect bites.

Mechanism of Action: High-Affinity $H_1$ Blockade

Levocetirizine is an inverse agonist that targets the peripheral histamine $H_1$ receptors.

Selective Binding: It selectively binds to $H_1$ receptors, preventing histamine—the primary mediator of the “allergic cascade”—from attaching.

Stabilization: It stabilizes the receptor in its inactive state, reducing capillary permeability and decreasing the inflammatory response (swelling and mucus production).

Peripheral Action: Because it has low lipid solubility and is a substrate for the P-glycoprotein pump, it does not easily cross the blood-brain barrier, which is why it is “non-sedating” for most patients.

The Manufacturer’s Perspective: Formulation & Export

From a production and global trade standpoint, Levocetirizine 5 mg is a high-demand, high-volume “essential” product:

• Enantiomeric Purity: As a WHO-GMP manufacturer, we ensure the complete separation of the (R)-enantiomer. This purity is what gives Levocetirizine its superior safety profile over older antihistamines.

• Formulation Varieties: For your B2B marketplace, we manufacture these as Immediate Release (IR) tablets, Mouth Dissolving Tablets (MDT), and Syrups for pediatric export.

• Stability for Global Trade: Levocetirizine is highly stable. We utilize Alu-Alu or high-barrier PVC/PVDC blister packaging to ensure a 36-month shelf life for export to Zone IVb regions (Africa and Southeast Asia).

• Dossier Support: This is a staple for pharmacy chains and distributors. Our Mumbai facility provides full CTD/eCTD Dossiers to support international registration against the innovator (Xyzal).