In the pharmaceutical industry, Chlordiazepoxide Hydrochloride 10 mg is a landmark medication, being the first benzodiazepine ever developed. As a pharmacist, I characterize it as a long-acting anxiolytic and sedative-hypnotic that is particularly valued for its smooth onset and prolonged duration of action, which helps prevent the “rebound” effects seen with shorter-acting agents.

Primary Clinical Uses

• Anxiety Disorders: Indicated for the short-term relief of severe anxiety or as a preoperative sedative to reduce patient apprehension.

• Acute Alcohol Withdrawal: This is perhaps its most critical modern use. It is the “gold standard” for managing the symptoms of alcohol withdrawal (delirium tremens), helping to prevent seizures and agitation.

• Psychosomatic Disorders: Used as adjunctive therapy in conditions where anxiety manifests as physical symptoms, such as in certain gastrointestinal or cardiovascular issues.

Mechanism of Action

Chlordiazepoxide works by enhancing the effect of the neurotransmitter GABA (Gamma-Aminobutyric Acid) in the central nervous system.

It binds to specific benzodiazepine receptors on the $GABA_A$ receptor complex. This binding increases the frequency of the opening of the chloride ion channel, leading to an influx of chloride ions into the neuron. This results in hyperpolarization of the post-synaptic neuron, making it less excitable and producing a calming, anti-convulsant, and muscle-relaxant effect.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing and global trade standpoint, Chlordiazepoxide 10 mg is a specialized CNS (Central Nervous System) product requiring strict regulatory oversight:

• Controlled Substance Handling: As a WHO-GMP manufacturer, we maintain rigorous “Schedule” drug protocols. Exporting Chlordiazepoxide requires specific Export Permits and “No Objection Certificates” (NOC) from the Narcotics Commissioner.

• Content Uniformity: Because it is effective at a 10 mg dose, we utilize validated high-shear granulation and blending to ensure every tablet in the batch is identical.

• API Stability: Chlordiazepoxide is light-sensitive. Our manufacturing facility in Mumbai uses UV-protected environments during processing, and we prioritize opaque Alu-Alu or Amber PVC/PVDC blister packaging to ensure a stable 24-month shelf life.

• Regulatory Readiness: We provide comprehensive CTD Dossiers and stability data to support our international partners in registering the product in African, Southeast Asian, and CIS markets.